Synthesis and Phytophathogenic Activities of Isopropylmethylphenyl benzenesulfonate Derivatives

Isopropylmethylphenyl benzenesulfonate 유도체의 합성과 식물병원균에 대한 생리활성

  • 최원식 (순천향대학교 생명공학과) ;
  • 남석우 (순천향대학교 생명공학과) ;
  • 김학천 (경보제약(주) 중앙연구소)
  • Received : 2010.10.06
  • Accepted : 2010.12.17
  • Published : 2010.12.31


Twenty five compounds isopropylmethylphenyl benzenesulfonate derivatives of thymol (1), 4-isopropyl-3-methylphenol (2), 5-isopropyl-3-methylphenol (3), 4-isopropylphenol (4), and 2-isopropylphenol (5) derivatives were synthesized. These compounds were analyzed for their structural confirmation with IR, GC/MS, and $^1H$-NMR. Synthetic compounds were tested against phytopathogenic fungi activities such as Pyrcularia grisea, Rhizoctonia solani, Phytophthora infestans, Colletotrichum orbiculare, and Sphaerotheca fusca. 2-Isopropyl-5-methylphenyl o-toluenesulfonate (1a), 2-isopropylphenyl 2,4,5-trichloro-benzenesulfonate (5b) and 2-isopropylphenyl 2-methyl-5-nitrobenzenesulfonate (5e) showed a potent in vivo antifungal activity against Pyrcularia grisea, Phytophthora infestans and Sphaerotheca fusca.


Isopropylmethylphenyl benzenesulfonate derivatives;Phytopathogen;Fungicidal activity


Supported by : 순천향대학교


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