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Mitochondrial Affinity of Guanidine-rich Molecular Transporters Built on myo- and scyllo-Inositol Scaffolds: Stereochemistry Dependency

  • Ghosh, Subhash C. (Department of Chemistry, Pohang University of Science and Technology) ;
  • Kim, Bo-Ram (Department of Chemistry, Pohang University of Science and Technology) ;
  • Im, Jung-Kyun (Department of Chemistry, Pohang University of Science and Technology) ;
  • Lee, Woo-Sirl (Department of Chemistry, Pohang University of Science and Technology) ;
  • Im, Chang-Nim (Department of Chemistry, National University of Singapore, Laboratory of Bioimaging Probe Development, Singapore Bioimaging Consortium, Agency for Science, Technology and Research (A*STAR) Biopolis) ;
  • Chang, Young-Tae (Department of Chemistry, National University of Singapore, Laboratory of Bioimaging Probe Development, Singapore Bioimaging Consortium, Agency for Science, Technology and Research (A*STAR) Biopolis) ;
  • Kim, Wan-Il (Department of Life Science, Pohang University of Science and Technology) ;
  • Kim, Kyong-Tai (Department of Life Science, Pohang University of Science and Technology) ;
  • Chung, Sung-Kee (Department of Chemistry, Pohang University of Science and Technology)
  • Received : 2010.07.06
  • Accepted : 2010.10.04
  • Published : 2010.12.20

Abstract

We prepared several novel molecular transporters built on myo- and scyllo-inositol scaffolds with variations in the number of guanidine residues, linker chain lengths and patterns. Some of these transporters were found to localize in mitochondria, and the mitochondrial affinity seems to be substantially related to the scaffold stereochemistry.

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