Study of Complementary Medical Therapy for Allergic Rhinitis in PubMed

PubMed를 통해 살펴 본 알레르기 비염에 대한 보완 의학적 최신 연구 경향

  • Jung, Hye-Mi (Dept. of Oriental Internal Medicine, College of Oriental Medicine, Dong-guk University) ;
  • Cho, Min-Jung (Dept. of Oriental Internal Medicine, College of Oriental Medicine, Dong-guk University) ;
  • Seo, Un-Kyo (Dept. of Oriental Internal Medicine, College of Oriental Medicine, Dong-guk University)
  • 정혜미 (동국대학교 한의과대학 내과학교실) ;
  • 조민정 (동국대학교 한의과대학 내과학교실) ;
  • 서운교 (동국대학교 한의과대학 내과학교실)
  • Published : 2009.09.30


Objectives : To study trends in complementary medical therapy for the allergic rhinitis. This study analyzed research on allergic rhinitis in PubMed. Methods : We searched PubMed related to complementary medical therapy for allergic rhinitis. We analyzed 25 research papers and examined published journals, years countries, and their methods, objectives, results, interventions, participants, periods and instruments of assessment. Results : The method of studies was mostly randomized, double-blind, placebo-controlled trial. There were research papers concerning treatment and prevention with herbal medicine, acupuncture, diet, etc. There were more positive results compared to negative results for treatment and prevention. Most studies were carried out during the winter/spring period. The median for number of participants was 90.54 persons. Diagnostic criteria for enrolment were nasal symptoms, allergic skin test, serum, nasal discharge allergen specific IgE eosinophil, etc. Assessment for outcomes were nasal symptoms, serum, nasal discharge allergen specific IgE eosinophil and Quality of Life Questionnaire. Conclusions : It is necessary to study effects of acupuncture and herb medicines for allergic rhinitis and more in-depth research about trends in complementary medical therapy for allergic rhinitis.



  1. Dykewicz MS, Fineman S, Nicklas R, Lee R, Blessing-Moore J, Li JT et al. Executive summary of joint task force practice parameters on diagnosis and management of rhinitis. Ann Allergy Asthma Immunol. 1998;81:463-8.
  2. Ray NF, Baraniuk JN, Thamer M, Rinehart CS, Gergen PJ, Kaliner M, Josephs S, Pung YH. Direct expenditures for the treatment of allergic rhinoconjunctivitis in 1996, including the contribution of related airway illnesses. J Allergy Clin Immunol. 1999;103:401-7.
  3. Crystal-Peters J, Crown WH, Goetzel RZ, Schutt DC. The cost of productivity losses associated with allergic rhinitis. Am J Manage Care. 2006;6(3):373-8.
  4. Woo HS, Kim CH. The Review of Oriental Medical Therapy on Allergic Rhinitis. J KoreanOriental Med. 2006;27(1):155-64.
  5. Rhee CS. Immunotherapy for Allergic Rhinitis : Current and Future. Korean J Otolarngol. 2005;48(11):1312-22.
  6. Goebel MD, Meykadeh N, Kou W, Schedlowski M, Hengge UR. Behavioral conditioning of antihistamine effects in patients with allergic rhinitis. Psychother Psychosom 2008;77(4):227-34.
  7. Yang SH, Yu CL. Antiinflammatory effects of Bu-zhong-yi-qi-tang in patients with perennial allergic rhinitis. J Ethnopharmacol. 2008 Jan 4;115(1):104-9.
  8. Xue CC, An X, Cheung TP, Da Costa C, Lenon GB, Thien FC, Story DF. Acupuncture for persistent allergic rhinitis: a randomised, sham-controlled trial. Med J Aust. 2007 Sep 17;187(6):337-41.
  9. Yoshimura M, Enomoto T, Dake Y, Okuno Y, Ikeda H, Cheng L, Obata A. An evaluation of the clinical efficacy of tomato extract for perennial allergic rhinitis. Allergol Int. 2007 Sep;56(3):225-30.
  10. Tamura M, Shikina T, Morihana T, Hayama M, Kajimoto O, Sakamoto A, Kajimoto Y, Watanabe O, Nonaka C, Shida K, Nanno M. Effects of probiotics on allergic rhinitis induced by Japanese cedar pollen: randomized double-blind, placebo-controlled clinical trial. Int Arch Allergy Immunol. 2007;143(1):75-82.
  11. Enomoto T, Nagasako-Akazome Y, Kanda T, Ikeda M, Dake Y. Clinical effects of apple polyphenols on persistent allergic rhinitis: A randomized double-blind placebo-controlled parallel arm study. J Investig Allergol Clin Immunol. 2006;16(5):283-9.
  12. Cordray S, Harjo JB, Miner L. Comparison of intranasal hypertonic dead sea saline spray and intranasal aqueous triamcinolone spray in seasonal allergic rhinitis. Ear Nose Throat J. 2005 Jul;84(7):426-30.
  13. Montano Velazquez BB, Jauregui-Renaud K, Banuelos Arias Adel C, Ayala JC, Martinez MD, Campillo Navarrete R, Rosalia IS, Salazar Mdel R, Serrano HA, Mondrag6n AO, Perez RL. Vitamin E effects on nasal symptoms and serum specific IgE levels in patients with perennial allergic rhinitis. Ann Allergy Asthma Immunol. 2006 Jan;96(1):45-50.
  14. Schapowal A: Study Group. Treating intermittent allergic rhinitis: a prospective, randomized, placebo and antihistamine-controlled study of Butterbur extract Ze 339. Phytother Res. 2005 Jun;19(6):530-7.
  15. Peng GC, Hsu CH. The efficacy and safety of heat-killed Lactobacillus paracasei for treatment of perennial allergic rhinitis induced by house-dust mite. Pediatr Allergy Immunol. 2005 Aug;16(5):433-8.
  16. Mao TK, Van de Water J, Gershwin ME. Effects of a Spirulina-based dietary supplement on cytokine production from allergic rhinitis patients. J Med Food. 2005 Spring;8(1):27-30.
  17. Kim LS, Riedlinger JE, Baldwin CM, Hilli L, Khalsa SV, Messer SA, Waters RF. Treatment of seasonal allergic rhinitis using homeopathic preparation of common allergens in the southwest region of the US: a randomized, controlled clinical trial. Ann Pharmacother. 2005 Apr;39(4):617-24.
  18. Kobayashi M, Matsushita H, Tsukiyama R, Saito M, Sugita T. Shoyu polysaccharides from soy sauce improve quality of life for patients with seasonal allergic rhinitis: a double-blind placebo-controlled clinical study. Int J Mol Med. 2005 Mar;15(3):463-7.
  19. Saxena VS, Venkateshwarlu K, Nadig P, Barbhaiya HC, Bhatia N, Borkar DM, Gill RS, Jain RK, Katiyar SK, Nagendra Prasad KV, Nalinesha KM, Nasiruddin K, Rishi JP, Roy Chowdhury J, Saharia PS, Thomas B, Bagchi D. Multicenter clinical trials on a novel polyherbal formulation in allergic rhinitis. Int J Clin Pharmacol Res. 2004;24(2-3):79-94.
  20. Badar VA, Thawani VR, Wakode PT, Shrivastava MP, Gharpure KJ, Hingorani LL, Khiyani RM. Efficacy of Tinospora cordifolia in allergic rhinitis. J Ethnopharmacol. 2005 Jan 15;96(3):445-9.
  21. Schapowal A; Petasites Study Group. Butterbur Ze339 for the treatment of intermittent allergic rhinitis: dose-dependent efficacy in a prospective, randomized, double-blind, placebo-controlled study. Arch Otolaryngol Head Neck Surg. 2004 Dec;130(12):1381-6.
  22. Ng DK, Chow PY, Ming SP, Hong SH, Lau S, Tse D, Kwong WK, Wong MF, Wong WH, Fu YM, Kwok KL, Li H, Ho JC. A double-blind, randomized, placebo-controlled trial of acupuncture for the treatment of childhood persistent allergic rhinitis. Pediatrics. 2004 Nov;114(5):1242-7.
  23. Kobayashi M, Matsushita H, Shioya I, Nagai M, Tsukiyama R, Saito M, Sugita T, Sugimura T, Yamamoto K. Quality of life improvement with soy sauce ingredients, Shoyu polysaccharides, in perennial allergic rhinitis: a double-blind placebo-controlled clinical study. Int J Mol Med. 2004 Nov;14(5):885-9.
  24. Brinkhaus B, Hummelsberger J, Kohnen R, Seufert J, Hempen CH, Leonhardy H, Nagel R, Joos S, Hahn E, Schupp an D. Acupuncture and Chinese herbal medicine in the treatment of patients with seasonal allergic rhinitis: a randomized-controlled clinical trial. Allergy. 2004 Sep;59(9):953-60.
  25. Gray RD, Haggart K, Lee DK, Cull S, Lipworth BJ. Effects of butterbur treatment in intermittent allergic rhinitis: a placebo-controlled evaluation. Ann Allergy Asthma Immunol. 2004 Jul;93(1):56-60.
  26. Shahar E, Hassoun G, Pollack S. Effect of vitamin E supplementation on the regular treatment of seasonal allergic rhinitis. Ann Allergy Asthma Immunol. 2004 Jun;92(6):654-8.
  27. Magnusson AL, Svensson RE, Leirvik C, Gunnarsson RK. The effect of acupuncture on allergic rhinitis: a randomized controlled clinical trial. Am J Chin Med. 2004;32(1):105-15.
  28. Lee DK, Gray RD, Robb FM, Fujihara S, Lipworth BJ. A placebo-controlled evaluation of butterbur and fexofenadine on objective and subjective outcomes in perennial allergic rhinitis. Clin Exp Allergy. 2004 Apr;34(4):646-9.
  29. Wang MF, Lin HC, Wang YY, Hsu CH. Treatment of perennial allergic rhinitis with lactic acid bacteria. Pediatr Allergy Immunol. 2004 Apr;15(2):152-8.
  30. Xue CC, Thien FC, Zhang JJ, Yang W, Da Costa C, Li CG. Effect of adding a Chinese herbal preparation to acupuncture for seasonal allergic rhinitis: randomised double-blind controlled trial. Hong Kong Med J. 2003 Dec;9(6):427-34.
  31. Lee SI. Common Allergic Diseases in Children. J Korean Med Assoc. 2003;46(3):231-43.
  32. Ricketti Aj. Allergic rhinitis. In: Grammar Lc, Greenberger PA, eds. Patterson's Allergic Disease. 6th. Philadelphia: Pippincott Williams & Wilkins;2002 p. 1-24
  33. Chae BY. The Korean Medical Opthalmology & Otolaryngology & Dermatology. Seoul: Jipmoondang;1997, p. 321-6.
  34. Skoner DP. Allergic rhinitis: definition, epidemiology, pathophysiology, detection and diagnosis. J Allergy Clin Immunol. 2001;108:2-8.
  35. 백만기. 최신이비인후과학. 서울: 군자출판사;2002, p. 189-213.
  36. Kay AB, Lessof MH. Allergy; conventional and alternative concepts; A report of the Royal College of Physicians Committee on Clinical Immunology and Allergy. Clin Exp Allergy. 1992;22(SuppI.3):1-44.
  37. Chae BY. A Clinical study of allergic rhinitis. J Korean Oriental Med. 2000;21(3):149-65.