Management of Veterinary Drug Residues in Food

식품 중 잔류동물용의약품의 안전관리

  • Oh, Jae-Ho (Food Chemical Residues Division, National Institute of Food and Drug Safety Evaluation) ;
  • Kwon, Chan-Hyeok (Food Chemical Residues Division, National Institute of Food and Drug Safety Evaluation) ;
  • Jeon, Jong-Sup (Food Chemical Residues Division, National Institute of Food and Drug Safety Evaluation) ;
  • Choi, Dong-Mi (Food Chemical Residues Division, National Institute of Food and Drug Safety Evaluation)
  • 오재호 (식품의약품안전평가원 화학물질과) ;
  • 권찬혁 (식품의약품안전평가원 화학물질과) ;
  • 전종섭 (식품의약품안전평가원 화학물질과) ;
  • 최동미 (식품의약품안전평가원 화학물질과)
  • Published : 2009.09.30


Veterinary drugs have been used to prevent livestock diseases for many years. In spite of having advantages, sometimes indiscriminate application, overdose and abuse may cause risk for human. Therefore, management and risk assessment of veterinary drugs become essential to ensure food safety. So the National Veterinary Research & Quarantine Service (NVRQS) impose on registration for use of veterinary drugs also Korea Food and Drug Administration (KFDA) fixed the maximum residue limits (MRLs) for veterinary drugs in food. Basically, KFDA set MRLs based on the veterinary drugs residual data. Moreover, KFDA estimates the theoretical maximum daily intake (TMDI) with food consumption data and population mean body weight. Recently, 116 veterinary drug MRLs including banned veterinary drugs have been established and other 32 veterinary drugs MRLs will be established within 2009. In 2010, MRLs among antibiotics and synthetic antibacterial agents in livestock fishery products (including milk and eggs) and honey (including royal jelly and propolis) which have not been set in Korea Food Code and Codex Alimentarius Commission (CAC) will be regulated as uniform limit (0.03 mg/kg). In future, veterinary drugs will be controlled strictly to strengthen public health by improving analytical method.


  1. CCRVDF (2001) Report of the Thirteenth Session of the Codex Committee on Residues of Veterinary Drugs in Foods, Codex, Rome, Italy
  2. NVRQS, Notice No. 2007-25 (2 Jan 2008).
  3. NVRQS (2004) Classification for Active Ingredient of Veterinary Drug, The National Veterinary Research & Quarantine Service, Anyang, Korea
  4. KAHPA (2001) Usage of Veterinary Drugs, Korea Animal Health Products Association, Seoul, Korea
  5. MIFAFF, ME, KFDA (2009) Report of Control of Antibiotic Resistance in 2008, Ministry for Food, Agriculture, Forestry and Fisheries, Ministry of Environment, Korea Food & Drug Administration, Seoul, Korea
  6. MIFAFF (1992) Notice No. 1992-13
  7. NVRQS (2002) Notice No. 2002-6
  8. S. H. Lee (2008) Control of nitrofuran veterinary drug in food, Food Industry, 202, 58-70
  9. NVRQS (2005) Notice No. 2005-3
  10. NVRQS (2008) Notice No. 2008-25
  11. KFDA (2008) Korea Food Code, Korean Food and Drug Administration, Seoul, Korea
  12. KFDA (2004) Notice No. 2004-18
  13. KFDA (2004) Notice No. 2004-81
  14. KFDA (2005) Advanced Notice No. 2005-99
  15. KFDA (2006) Notice No. 2006-35
  16. KFDA (2006) Advanced Notice No. 2006-222
  17. KFDA (2007) Notice No. 2007-63
  18. KFDA (2007) Notice No. 2007-68
  19. Food and Agriculture organization of the united nations world health organization (2004) Technical Workshop on Residues of Veterinary Drugs without ADI/MRL, FAO/WHO, Rome, Italy
  20. Codex Alimentarius Committee (1993) Codex Guidelines for the Establishment of Regulatory Programme for Control of Veterinary Drug Residues in Foods, CAC/GL 16, Codex, Rome, Italy
  21. Japan MHLW, Notification No.499, 2005
  22. US FDA, Code of Federal Regulation Part 530.41; Drugs prohibited for extralabel use in animals
  23. European Union (1990) Council Regulation No. 2377/90; A community procedure for the establishment of maximum residue limits of veterinary medicinal procuts in foodstuffs of animal origin. Official Journal of the European Union L 224
  24. European Commission, 'Performance criteria and other requirements for analytical methods', SANCO/2004/2726 rev. 1
  25. KFDA (2009) Advanced Notice No. 2009-173
  26. KFDA (2008) Notice No. 2008-51

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