Apolipoprotein E Polymorphism and Cognitive Function Change of the Elderly in a Rural Area, Korea

일개 농촌지역 노인의 아포지단백 E 다형성과 인지기능 변화

  • Kim, Sang-Kyu (Department of Preventive Medicine, Dongguk University, College of Medicine) ;
  • Hwang, Tae-Yoon (Department of Preventive Medicine and Public Health Yeungnam University, College of Medicine) ;
  • Lee, Kyeong-Soo (Department of Preventive Medicine and Public Health Yeungnam University, College of Medicine) ;
  • Kang, Pock-Soo (Department of Preventive Medicine and Public Health Yeungnam University, College of Medicine) ;
  • Cho, Hee-Soon (Department of Laboratory Medicine Yeungnam University, College of Medicine) ;
  • Bae, Young-Kyung (Department of Pathology Yeungnam University, College of Medicine)
  • 김상규 (동국대학교 의과대학 예방의학교실) ;
  • 황태윤 (영남대학교 의과대학 예방의학교실) ;
  • 이경수 (영남대학교 의과대학 예방의학교실) ;
  • 강복수 (영남대학교 의과대학 예방의학교실) ;
  • 조희순 (영남대학교 진단검사의학교실) ;
  • 배영경 (영남대학교 병리학교실)
  • Published : 2009.07.31

Abstract

Objectives : The aim of this study is to examine the cognitive function change related to aging, the incidence of cognitive impairment, and the association between apolipoprotein E polymorphism and cognitive impairment through a follow-up of the elderly with normal cognitive ability at baseline. Methods : Two hundred and fifteen subjects aged 65 and over were surveyed in February, 1998 (baseline survey), and their cognitive function was assessed again in 2003 1st follow-up) and the once again in 2006 (2nd follow-up). Ninety one subjects completed all surveys up through the 2nd follow-up and their cognitive function scores using MMSE-K (Korean Version of the Mini-Mental State Examination) and the distribution of apolipoprotein E allele were analyzed. Results : The cognitive function scores decreased with aging and the difference between baseline and the 2nd follow-up scores of the study increased with the age group. The incidence rate of cognitive impairment through an 8-year follow-up was 38.5% and higher in older age groups. Age was the only significant factor for incidence of cognitive impairment, but there was no significant association between apolipoprotein E genotype and incidence of cognitive impairment. Conclusions : The cognition of the elderly decreased with aging and the association of apolipoprotein E genotype with incidence of cognitive impairment was not significant in this study. To confirm the association between apolipoprotein E polymorphism and incidence of cognitive impairment further studies will be needed.

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