Diagnostic Accordance Rate and Accuracy Between Cytological and Histological Test in Lung Disease

폐질환에 있어 세포검사와 조직검사의 진단 일치율 및 정확도에 대한 조사 연구

  • Kim, Sung-Chul (Department of Pathology, Hanyang University Guri Hospital) ;
  • Ro, Joung-Whan (Department of Pathology, Hanyang University Guri Hospital) ;
  • Kim, Tai-Jeon (Department of Biomedical Laboratory Sciences, College of Health Sciences, Eulji University)
  • 김성철 (한양대학교 구리병원 병리과) ;
  • 노정환 (한양대학교 구리병원 병리과) ;
  • 김태전 (을지대학교 보건과학대학 임상병리학과)
  • Received : 2009.10.30
  • Accepted : 2009.12.16
  • Published : 2009.12.31

Abstract

Lung cancer is a type of cancer with high mortality; its 5-year survival rate is at a low 14%. Related cytological tests include sputum, bronchial brushing, bronchial washing and fine needle aspiration cytology test etc. From the test specimens in which sputum, bronchial brushing, bronchial washing, and fine needle aspiration cytology were performed, the sensitivity, specificity and accuracy between cytology test and histology test. In the sputum test, sensitivity was 27.71% and specificity was 98.02%, and the bronchial brushing test showed sensitivity of 93.33% and a specificity of 91.3%. The bronchial washing test was a sensitivity of 53.7% and its specificity was 98.9%, and the fine needle aspiration cytology test showed sensitivity and specificity were 88.46% and 72.97%, respectively. In the specimens diagnosed as normal at the sputum test, malignant diagnosis was found in 21 specimens of bronchial brushing, 30 cases of bronchial washings and 37 cases of fine needle aspiration cytology specimens. In the specimens diagnosed as normal at the bronchial washing test, malignant diagnosis was found in 5 specimens of sputum, 7 specimens of bronchial brushin and 1 cases of fine needle aspiration cytology. One specimens found to be normal in fine needle aspiration cytology turned out to maligant in sputum test. The result of this research shows that, in diagnosis lung cancer, a test method of high sensitivity and specificity should be pursued. However, depending on the location and malignancy of the illness, diagnosis may not be obtained in some cases. Therefore, we conclude that the cytological tests performed for lung cancer testing such as sputum, bronchial brushing, bronchial washing, and fine needle aspiration cytology should be carried out in a mutually complementary manner.