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Association Study Between Polymorphisms of Inositol 1,4,5-triphosphate Receptor Type 1 (IP3R1) Gene and Carcass Traits in Korean Cattle (Hanwoo)

한우 Inositol 1,4,5-triphosphate Receptor Type 1 (IP3R1) 유전자의 다형성 및 형질 관련성 분석

  • 김남국 (농촌진흥청 국립축산과학원) ;
  • 김건석 (농촌진흥청 국립축산과학원) ;
  • 정유성 (농촌진흥청 국립축산과학원) ;
  • 문희주 (농촌진흥청 국립축산과학원) ;
  • 조용민 (농촌진흥청 국립축산과학원) ;
  • 윤두학 (농촌진흥청 국립축산과학원)
  • Received : 2009.07.17
  • Accepted : 2009.08.11
  • Published : 2009.08.01

Abstract

Inositol 1,4,5-triphosphate receptor type 1 (IP3R1) is a $Ca^{2+}$ release channel that responds to the second messenger IP3 and that modulates diverse cellular functions such as contraction/excitation, secretion, gene expression and cellular growth. We discovered single nucleotide polymorphisms (SNPs) within IP3R1 gene and analyzed associations between gene polymorphisms and carcass traits in Korean cattle (Hanwoo) in order to develop novel DNA markers at genomic level. Three SNPs were detected at the position of g.1428617A>G, g.1418843C>T and g.1414377C>T with 24 unrelated Hanwoo samples by direct sequencing of the PCR products. We found that genotype of g.1414377C>T SNP was associated with live weight (P<0.05) and carcass weight (P<0.01) using the general linear model of SAS package. These results suggest that polymorphism of IP3R1 gene was associated with weight-related traits in Hanwoo.

Keywords

IP3R1;SNP;Korean cattle (Hanwoo);Carcass trait

Acknowledgement

Supported by : 농촌진흥청(국립축산과학원)

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