Association between Genotypes and Gastric Mucosal Lymphocytes in Helicobacter pylori-infected Children

Helicobacter pylori 감염 소아에서 유전형과 위점막 림프구

  • Yom, Hye-Won (Department of Pediatrics, Seoul Metropolitan Dong-bu Hospital) ;
  • Cho, Min-Sun (Department of Pathology, Ewha Womans University School of Medicine) ;
  • Lee, Mi-Ae (Department of Laboratory Medicine, Ewha Womans University School of Medicine) ;
  • Seo, Jeong-Wan (Department of Pediatrics, Ewha Womans University School of Medicine)
  • 염혜원 (서울특별시 동부병원 소아청소년과) ;
  • 조민선 (이화여자대학교 의학전문대학원 병리학교실) ;
  • 이미애 (이화여자대학교 의학전문대학원 진단검사의학교실) ;
  • 서정완 (이화여자대학교 의학전문대학원 소아과학교실)
  • Received : 2009.07.31
  • Accepted : 2009.08.26
  • Published : 2009.09.30

Abstract

Purpose: Helicobacter pylori infection is probably acquired in childhood and persists as an asymptomatic infection for decades in most individuals. It is unclear why only a minority of those infected develop a clinical manifestation, even in childhood, such as peptic ulcer disease. H. pylori infection activates local immune responses and causes lymphocyte infiltration in the gastric mucosa. We have previously reported that both T and B cells in the lamina propria play important roles in the local immune response of H. pylori-infected children. The aim of this study was to investigate the association between H. pylori genotypes and gastric mucosal lymphocytes. Methods: Twenty-five H. pylori-infected children (10 with peptic ulcer disease and 15 with gastritis) were enrolled in this study. We investigated the genotypes (cagA, cagE, vacA, and babA2) and evaluated the association with clinical manifestations, histopathology, and gastric mucosal lymphocytes. Results: The prevalence of cagA, cagE, vacA s1m1, and babA2 was 80%, 60%, 84%, and 88%, respectively. The most prevalent (68%) combination of cagA, vacA, and babA2 genotypes was cagA+/vacA s1m1+/babA2+. H. pylori genotypes were not associated with clinical manifestations, histopathology, or gastric mucosal lymphocytes. Conclusion: There was no association between the cagA, cagE, vacA, or babA2 status and gastric mucosal lymphocytes. The role of the host immune response in relation to H. pylori genotypes and disease potential in children needs further studies.

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