Effects of Pear Alcoholic Fermentation Beverage on Airway Hyperresponsiveness and Immunoglobulin Production in Asthmatic Mice

배발효 음료가 천식이 유발된 생쥐의 기도 과민성 및 면역 글로불린 분비에 미치는 영향

  • Joung, Young-Min (School of Oriental Medicine, Pusan National University) ;
  • Kim, Hyung-Woo (School of Oriental Medicine, Pusan National University) ;
  • Chung, Hee-Jin (School of Oriental Medicine, Pusan National University) ;
  • Choi, Eu-Gene (School of Oriental Medicine, Pusan National University) ;
  • Do, Yoon-Ho (Center for Organic Agri-Food Industrialization, Dongshin University) ;
  • Choi, Jeong-Sik (Center for Organic Agri-Food Industrialization, Dongshin University) ;
  • Cho, Su-In (School of Oriental Medicine, Pusan National University)
  • 정영민 (부산대학교 한의학전문대학원) ;
  • 김형우 (부산대학교 한의학전문대학원) ;
  • 정희진 (부산대학교 한의학전문대학원) ;
  • 최유진 (부산대학교 한의학전문대학원) ;
  • 도윤호 (동신대학교 친환경농식품산업화센터) ;
  • 최정식 (동신대학교 친환경농식품산업화센터) ;
  • 조수인 (부산대학교 한의학전문대학원)
  • Published : 2009.12.30

Abstract

Objectives : This study was designed to investigate the effects of alcoholic fermentation beverage using pear, Bae Ro Mi In (BRMI) on airway hyperresponsiveness and immunoglobulin production in asthmatic mice Methods : We investigated the effects of BRMI on airway hyperresponsiveness by measurement of enhanced pause (Penh), and also investigated the effects on production levels of antigen specific antibody and subclasses such as IgG1, IgG2a and IgE by using ELISA methods. Prednisolone (PD, 5 mg/kg) was used as positive control. Results : Treatment with BRMI did not lowered airway hyperresponsiveness, but PD lowered significantly. Oral administration of BRMI lowered production level of ovalbumin (OVA) specific total antibody significantly. Especially, BRMI decreased IgE levels compared to non-treated control effectively. Treatment with PD lowered production levels of total antibody, IgG1 and IgE. Conclusions : These result suggest that BRMI can lower production levels of antigen specific total antibody and IgE in asthmatic mice. We also suggest that BRMI has the possibility to prevent or cure asthma through regulation of antigen specific antibody production.

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