Signal crosstalk between estrogen and peroxisome proliferator-activated receptor α on adiposity

  • Kim, Bang-Hyun (Department of Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Won, Young-Suk (Bio-Evaluation Center, KRIBB, Cheongwon) ;
  • Kim, Dae-Yong (Department of Veterinary Pathology, College of Veterinary Medicineand School of Agricultural Biotechnology, Seoul National University) ;
  • Kim, Bora (Division of Life and Pharmaceutical Sciences, Ewha Womans University) ;
  • Kim, Eun-Young (Division of Life and Pharmaceutical Sciences, Ewha Womans University) ;
  • Yoon, Mi-Jung (Department of Life Science, Mokwon University) ;
  • Oh, Goo-Taeg (Division of Life and Pharmaceutical Sciences, Ewha Womans University)
  • Published : 2009.02.28


Peroxisome proliferator-activated receptor $\alpha$ and estrogen are believed to be involved in metabolic changes leading to obesity. To test this relationship, we divided female wildtype and PPAR$\alpha$-deficient mice fed on a high fat diet into the following groups: mock-operated, ovariectomized (OVX), and $E_2$-treated. The visceral white adipose tissue and plasma cholesterol levels were increased significantly in wild type OVX and decreased in the $E_2$-treated group, but interestingly not in PPAR$\alpha$-deficient mice. The mRNA levels of lipoprotein lipase in adipose tissue were also increased in only wild type OVX and decreased significantly in $E_2$-treated mice. These novel results suggest the possibility of signaling crosstalk between PPAR$\alpha$ and $E_2$, causing obesity in vivo.


Estrogen;LPL;Obesity;PPAR$\alpha$;Signaling crosstalk


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