Elucidation of new anti-impotency analogue in food

식품 중 발기부전치료제 유사물질 규명

  • Suh, Junghyuck (Food Safety Evaluation Department, National Institute of Food and Drug Safety Evaluation) ;
  • Choi, Jangduck (Food Safety Evaluation Department, National Institute of Food and Drug Safety Evaluation) ;
  • Park, Kunsang (Food Safety Evaluation Department, National Institute of Food and Drug Safety Evaluation) ;
  • Hu, Soojung (Food Safety Evaluation Department, National Institute of Food and Drug Safety Evaluation) ;
  • Yoon, Taehyung (Food Safety Evaluation Department, National Institute of Food and Drug Safety Evaluation) ;
  • Kim, Eunju (Food Safety Evaluation Department, National Institute of Food and Drug Safety Evaluation) ;
  • Han, Seungwoo (Food Safety Evaluation Department, National Institute of Food and Drug Safety Evaluation) ;
  • Kim, Sohee (Food Safety Evaluation Department, National Institute of Food and Drug Safety Evaluation) ;
  • Lee, Kwangho (Food Safety Evaluation Department, National Institute of Food and Drug Safety Evaluation) ;
  • Kwan, Sungwon (Institute of Pharmaceutical Sciences, Seoul National University) ;
  • Kim, Deukjoon (Institute of Pharmaceutical Sciences, Seoul National University)
  • 서정혁 (식품의약품안전평가원 식품위해평가부) ;
  • 최장덕 (식품의약품안전평가원 식품위해평가부) ;
  • 박건상 (식품의약품안전평가원 식품위해평가부) ;
  • 허수정 (식품의약품안전평가원 식품위해평가부) ;
  • 윤태형 (식품의약품안전평가원 식품위해평가부) ;
  • 김은주 (식품의약품안전평가원 식품위해평가부) ;
  • 한승우 (식품의약품안전평가원 식품위해평가부) ;
  • 김소희 (식품의약품안전평가원 식품위해평가부) ;
  • 이광호 (식품의약품안전평가원 식품위해평가부) ;
  • 권성원 (서울대학교 약학대학) ;
  • 김득준 (서울대학교 약학대학)
  • Received : 2009.04.18
  • Accepted : 2009.05.05
  • Published : 2009.08.25

Abstract

The new anti-impotency analogue was identified in food source. Detection of this analogue was accomplished through screening of food samples by liquid chromatography/photodiode array detector. The spectrum pattern of analogue compound was similar to that observed for hongdenafil which was analogue of sildenafil. This new compound was isolated and purified using the liquid-liquid extraction, thin layer chromatography, column chromatography and preparative HPLC. And then those structure were identified using analytical instruments such as HPLC/PDA, LC/MS/MS and NMR. The compound was given a name to oxohongdenafil which was replaced with acetyl oxoethylpiperazinyl residue instead of sulfonyl piperazine group of sildenafil. The regulation for the abovementioned analogue, oxohongdenafil, was established by Standard of Korean food code.

Keywords

anti-impotency;elucidation;food;regulation;oxohongdenafil

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