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Effect of Copper on Plasma Ceruloplasmin and Antioxidant Ability in Broiler Chickens Challenged by Lipopolysaccharide

  • Song, Zhigang (Department of Animal Science, Shandong Agricultural University) ;
  • Zhu, Lixian (Department of Food Science, Shandong Agricultural University) ;
  • Zhao, Tong (Department of Animal Science, Shandong Agricultural University) ;
  • Jiao, Hongchao (Department of Animal Science, Shandong Agricultural University) ;
  • Lin, Hai (Department of Animal Science, Shandong Agricultural University)
  • 투고 : 2009.04.09
  • 심사 : 2009.06.04
  • 발행 : 2009.10.01

초록

The effects of dietary copper (Cu) supplementation in broiler chickens challenged with a single injection of Salmonella typhymurium lipopolysaccharide (LPS) on the antioxidant capacity and plasma levels of ceruloplasmin (Cp) were evaluated. The broiler chickens were provided with a basal diet or diets supplemented with 8 and 50 mg/kg Cu from 1d of age. At 25d of age, 48 chickens with similar body weight were selected from each diet. Half of the chickens in each dietary treatment were injected intraperitoneally (i.p.) with LPS (1 mg/kg body weight). The other half was injected with saline, serving as the control. Body weight gain and feed consumption were significantly suppressed by LPS challenge during the first 12-h after injection, regardless of dietary Cu levels. Feed efficiency was reduced by LPS injection during the 72-h experimental period. Dietary Cu levels had no significant effect (p>0.05) on the plasma ceruloplasmin concentrations in chickens injected with saline. In contrast, high dietary level of Cu elevated plasma Cp levels in chickens with LPS challenge. Short-term LPS challenge had no significant effect on the antioxidant ability of broilers, as indicated by superoxide dismutase, ferric reducing/antioxidant power and the thiobarbituric acid reacting substances in the plasma. The result suggests that high dietary Cu level (as much as 50 mg/kg supplementation) is favorable for coping with short-term LPS challenge through upregulating plasma Cp levels.

키워드

Copper;Ceruloplasmin;Lipopolysaccharide;Antioxidant Capacity;Broiler Chickens

참고문헌

  1. Cousins, R. J. and M. R. Swerdel. 1985, Ceruloplasmin and metallothionein induction by zinc and 13-cis-retinoic acid in rats with adjuvant inflammation, Proc. Soc. Exp. Biol. Med 179:168-172
  2. Engle, T. E. and L. R. Johnson. 2003, The effects of copper source and concentration on lipid metabolism in growing and finishing angus steers, Asian-Aust. J. Anim. Sci 16:1131-1136
  3. Gitlin, J. D., J. J. Schroeder, L. M. Lee-Ambrose and R. J. Cousins. 1992, Mechanisms of caeruloplasmin biosynthesis in normaland copper-deficient rats, Biochem. J 282:835-839
  4. Klasing, K. C. 1998, Comparative avian nutrition, CAB International, New York
  5. Nathan, E. H., K. Satoshi, M. M. Grazia, A. J. Hoogeboom, G. J. Jong and D. G. Jonathan. 2002, Mechanisms of copper incorporation into human ceruloplasmin, J. Biol. Chem 277:46632-46638 https://doi.org/10.1074/jbc.M206246200
  6. Simoyi, M. F., E. Falkenstein, K. V. Dyke, K. P. Blemings and H. Klandorf. 2003, Allantoin, the oxidation production of uric acid is present in chicken and turkey plasma, Comp. Biochem. Physiol B 135:325-335 https://doi.org/10.1016/S1096-4959(03)00086-1
  7. Sugiyama, T., Y. Kawarada and F. Hirasawa. 2000, Experimental protocols for reactive oxygen and nitrogen species, Oxford University Press, New York
  8. Lin, H., E. Decuypere and J. Buyse. 2004b, Oxidative stress induced by corticosterone administration in broiler chickens(Gallus gallus domesticus) 2. short-term effect, Comp. Biochem. Physiol. B 139:745-751 https://doi.org/10.1016/j.cbpc.2004.09.014
  9. Ponukalina, E. V., G. A. Afanas'eva, N. P. Chesnokova and V. F. Kirichuk. 2001, Lipid peroxidation and the antioxidant blood system in dynamics of pestilential and choleraic intoxication, Patol. Fiziol. Eksp. Ter 3:17-18
  10. Benzie, I. F. and J. J. Strain. 1999, Ferric reducing/antioxidant power assay: direct measure of total antioxidant activity of biological fluids and modified version for simultaneous measurement of total antioxidant power and ascorbic acid concentration, Meth. Enzymol 299:15-27 https://doi.org/10.1016/S0076-6879(99)99005-5
  11. Laurin, D. E. and K. C. Klasing. 1987, Effects of repetitive immunogen injections and fasting vs. feeding on iron, zinc, and copper metabolism, Biol. Trace Elem. Res 14:153-165 https://doi.org/10.1007/BF02795605
  12. Beisel, W. R. 1977, Magnitude of the host nutritional responses to infection, Am. J. Clin. Nutr. 30:1236-1247 https://doi.org/10.1016/S0899-9007(97)00436-X
  13. Benzie, I. F. and J. J. Strain. 1996, The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay, Anal. Biochem 239:70-76 https://doi.org/10.1006/abio.1996.0292
  14. National Research Council. 1994, Nutrition requirements of poultry. 9th Ed,National Academy Press, Washington, DC
  15. Xie, H., N. C. Rath, G. R. Huff, W. E. Huff and J. M. Balog. 2000, Effects of salmonella typhimurium lipopolysaccharide on broiler chickens, Poult. Sci 79:33-40
  16. Bouchon, A., F. Facchetti, M. A. Weigand and M. Colonna. 2001, TREM-1 amplifies inflammation and is a crucial mediator of septic shock, Nature 410:1103-1107 https://doi.org/10.1038/35074114
  17. Zhao, T. 2005, Effects of dietary copper and immunological stress on antioxidant stress activity of broilers. Master. Thesis, Shandong Agricultural University, Shandong, China
  18. Anderson, R. A., N. A. Bryden, C. M. Evock-Clover and N. C. Steele. 1997, Beneficial effects of chromium on glucose and lipid variables in control and somatotropin-treated pigs are associated with increased tissue chromium and altered tissue copper, iron and zinc, J. Anim. Sci 75:657-661
  19. Kevyn, L., P. H. Adler, R. K. Peng and K. C. Klasing. 2001, The kinetics of hemopexin and a1-acid glycoprotein levels induced by injection of inflammatory agents in chickens, Avian Dis 45:289-296 https://doi.org/10.2307/1592967
  20. Lin, H., S. J. Sui, H. C. Jiao, J. Buyse and E. Decuypere. 2006, Impaired development of broiler chickens by stress mimicked by corticosterone exposure, Comp. Biochem. Physiol. A 143:400-405 https://doi.org/10.1016/j.cbpa.2005.12.030
  21. Tom, B. 1993, Nutritional biochemistry, California: Academic Press
  22. SAS Institute. 1998, User's Guide: Statistic, SAS Institute Inc., Cary, North Carolina
  23. Ferket, P. R. and A. G. Gernat. 2006, Factors that affect feed intake of meat birds: a review, Int. J. Poult. Sci 5:905-911 https://doi.org/10.3923/ijps.2006.905.911
  24. Simoyi, M. F., K. V. Dyke and H. Klandorf. 2002, Manipulation of plasma uric acid in broiler chicks and its effect on leukocyte oxidative activity, Am. J. Physiol 282:R791-R796
  25. Lim, H. S. and I. K. Paik. 2006, Effects of dietary supplementation of copper chelates in the form of methionine, chitosan and yeast in laying hens, Asian-Aust. J. Anim. Sci 19:1174-1178
  26. Koh, T. S., R. K. Peng and K. C. Klasing. 1996, Dietary copper level affects copper metabolism during lipopolysaccharideinduced immunological stress in chicks, Poult. Sci 75:867-872 https://doi.org/10.3382/ps.0750867
  27. McMahon, C. D., D. F. Buxton, T. H. Elsasser, D. R. Gunter, L. G. Sanders, B. P. Steele and J. L. Sartin. 1999, Neuropeptide Y restores appetite and alters concentrations of GH after central administration to endotoxic sheep, J. Endocrinol 161:333-339 https://doi.org/10.1677/joe.0.1610333
  28. Volkoffa, H. and R. E. Peter. 2004, Effects of lipopolysaccharide treatment on feeding of goldfish: role of appetite-regulating peptides, Brain Res 998:139-147 https://doi.org/10.1016/j.brainres.2003.11.011
  29. Xia, M. S., C. H. Hu, Z. R. Xu, Y. Ye, Y. H. Zhou and L. Xiong. 2004, Effects of copper-bearing montmorillonite (Cu-MMT) on escherichia coli and diarrhea on weanling pigs, Asian-Aust. J. Anim. Sci 17:1712-1716
  30. Baker, D. H. and C. B. Ammerman. 1995, Copper bioavailability, In: Bioavailability of Nutrients for Animals, Academic Press,San Diego. pp. 127-156
  31. Hu, C. H., M. S. Xia, Z. R. Xu and L. Xiong. 2004, Effects of copper-bearing montmorillonite on growth performance and digestive function of growing pigs, Asian-Aust. J. Anim. Sci17:1575-1581
  32. Hellsten, Y., P. C. Tullson, E. A. Richter and J. Bangsbo. 1997, Oxidation of urate in human skeletal muscle during exercise,Free Radic. Biol. Med 22:169-174 https://doi.org/10.1016/S0891-5849(96)00286-9
  33. Lin, H., E. Decuypere and J. Buyse. 2004a, Oxidative stress induced by corticosterone administration in broiler chickens: 1. chronic exposure, Comp. Biochem. Physiol. B 139:737-744 https://doi.org/10.1016/j.cbpc.2004.09.013

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