In Vitro Antineoplastic Effects of Chitosan Hydrolysates on Various Tumor Cell Lines

키토산 가수분해물의 In Vitro 항종양성

  • Park, Heon-Kuk (Dept. of Food and Nutrition, Dongnam Health University)
  • 박헌국 (동남보건대학 식품영양과)
  • Published : 2009.12.31

Abstract

In this study, the antineoplastic effects of chitosan hydrolysates were assessed. The chitosan hydrolysates showed no cytotoxicity in in vitro trials using the normal cell line, Vero E6(Africa green monkey kidney cells). The $IC_{50}$ value of the chitosan hydrolysates on Vero E6 was 1,107.95 ${\mu}g/m{\ell}$. The hydrolysates exhibited in vitro antineoplastic activity in five human tumor (lung carcinoma, bladder carcinoma, colon carcinoma, stomach carcinoma, breast carcinoma) cell lines. The $IC_{50}$ values of the hydrolysates on A549, J82, SNU-C4, SNU-1, and ZR75-1 cells were 421.06, 417.99, 445.54, 380.65 and 460.49 ${\mu}g/m{\ell}$, respectively.

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