Anti-Inflammatory Action of the Fractions of Platycodi radix

길경(Platycodi radix) 분획물의 항염증 활성

  • Kim, Sung-Yeun (Dept. of Food Science, Seoul Women's University) ;
  • Lee, Eun-Bang (Natural Products Research Institute, Seoul National University) ;
  • Jeong, Eun-Ja (Dept. of Food Science, Eulji University)
  • 김성연 (서울여자대학교 대학원 식품과학과) ;
  • 이은방 (서울대학교 천연물과학연구소) ;
  • 정은자 (을지대학교 보건산업대학 식품과학부)
  • Published : 2009.12.31

Abstract

The extract of Platycodi radix has long been used as an anti-inflammatory traditional medicine in Korea for the treatment of bronchitis, asthma and acute respiratory disease. In this study, the anti-inflammatory actions of the methanol extract of Platycodi radix administered via oral administration were evaluated. The results revealed that the extracts exhibited potent anti-inflammatory action. Of the hexane, chloroform, ethyl acetate, butanol and water fractions, the butanol fraction had the most potent anti-inflammatory action. Additioinally the sapogenin obtained through acid hydrolysis of the butanol fraction did not show anti-inflammatory action. These findings confirm the value of Platycodi radix as a traditional Korean medicine.

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