Antioxidative Constituents from the Whole Plants of Euphorbia supina

애기땅빈대의 항산화 활성 성분

  • Hong, Hyun-Kyung (College of Pharmacy, Sungkyunkwan University) ;
  • Kwak, Jong-Hwan (College of Pharmacy, Sungkyunkwan University) ;
  • Kang, Se-Chan (Department of Natural Medicine Resources, Semyung University) ;
  • Lee, Jong-Wook (College of Pharmacy, Sungkyunkwan University) ;
  • Park, Jong-Hyuk (College of Pharmacy, Sungkyunkwan University) ;
  • Ahn, Jong-Woong (Division of Marine Environment and Bioscience, Korea Maritime University) ;
  • Kang, Hye-Sook (Research Institute of Marine Science and Technology, Korea Maritime University) ;
  • Choung, Eui-Su (College of Pharmacy, Sungkyunkwan University) ;
  • Zee, Ok-Pyo (College of Pharmacy, Sungkyunkwan University)
  • 홍현경 (성균관대학교 약학대학) ;
  • 곽종환 (성균관대학교 약학대학) ;
  • 강세찬 (세명대학교 자연약재과학과) ;
  • 이종욱 (성균관대학교 약학대학) ;
  • 박종혁 (성균관대학교 약학대학) ;
  • 안종웅 (한국해양대학교 해양환경생명과학부) ;
  • 강혜숙 (한국해양대학교 해양과학기술연구소) ;
  • 정의수 (성균관대학교 약학대학) ;
  • 지옥표 (성균관대학교 약학대학)
  • Published : 2008.09.30


Eight compounds were isolated from the EtOAc soluble fraction of Euphorbia supina MeOH extract as the radical scavengers for antioxidant activity. Their structures were identified as kaempferol (1), quercetin (2), juglanin (3), avicularin (4), astragalin (5), isoquercitrin (6), hyperin (7), and nicotiflorin (8) by spectroscopic analysis. The antioxidant activity was evaluated by the ORAC (oxygen radical absorbance capacity) assay, which measures scavenging activity against peroxy radicals induced by 2,2'-azobis (2-methylpropionamidine) dihydrochloride, and the ORAC value is expressed as relative trolox equivalent. Compounds 4, 6, and 7 exhibited potent antioxidant activity, whereas the other compounds showed weaker activity than trolox.


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