Clinical Features of Thymic Epithelial Tumors

흉선 상피 종양의 임상적 고찰

  • Mok, Jeong Ha (Department of Internal Medicine, Pusan National University School of Medicine) ;
  • Seol, Hee Yun (Department of Internal Medicine, Pusan National University School of Medicine) ;
  • Kim, Ji Eun (Department of Internal Medicine, Pusan National University School of Medicine) ;
  • Kim, Ki Uk (Department of Internal Medicine, Pusan National University School of Medicine) ;
  • Park, Hye-Kyung (Department of Internal Medicine, Pusan National University School of Medicine) ;
  • Lee, Ho Seok (Department of Thoracic Surgery, Pusan National University School of Medicine) ;
  • Kim, Young Dae (Department of Thoracic Surgery, Pusan National University School of Medicine) ;
  • Kim, Yun Seong (Department of Internal Medicine, Pusan National University School of Medicine) ;
  • Lee, Chang Hun (Department of Pathology, Pusan National University School of Medicine) ;
  • Lee, Min Ki (Department of Internal Medicine, Pusan National University School of Medicine) ;
  • Park, Soon Kew (Department of Internal Medicine, Pusan National University School of Medicine)
  • 목정하 (부산대학교 의학전문대학원 내과학교실) ;
  • 설희윤 (부산대학교 의학전문대학원 내과학교실) ;
  • 김지은 (부산대학교 의학전문대학원 내과학교실) ;
  • 김기욱 (부산대학교 의학전문대학원 내과학교실) ;
  • 박혜경 (부산대학교 의학전문대학원 내과학교실) ;
  • 이호석 (부산대학교 의학전문대학원 흉부외과학교실) ;
  • 김영대 (부산대학교 의학전문대학원 흉부외과학교실) ;
  • 김윤성 (부산대학교 의학전문대학원 내과학교실) ;
  • 이창훈 (부산대학교 의학전문대학원 병리학교실) ;
  • 이민기 (부산대학교 의학전문대학원 내과학교실) ;
  • 박순규 (부산대학교 의학전문대학원 내과학교실)
  • Received : 2008.06.03
  • Accepted : 2008.06.25
  • Published : 2008.07.30


Background: Thymic epithelial tumors are the most common tumors affecting the anterior mediastinum. The aim of this study is to investigate clinical features of the patients who were diagnosed with thymic epithelial tumors at Pusan National University Hospital. Methods: We retrospectively reviewed the records of thirty-seven patients who were diagnosed with thymic epithelial tumors from Jan. 1997 to Jan. 2007. The pathological classification and clinical stage of the thymic epithelial tumors were based on the WHO classification and Masaoka's staging system. A total 37 patients were enrolled: 23 were males and 14 were females, and their mean age was 51.3 years. Results: Thirty patients presented symptoms at the time of diagnosis and their symptoms were as follows: chest pain (53%), dyspnea (23%), and cough (17%). Myasthenia gravis was diagnosed in five patients. With respect to the tumor staging, three cases (8%) were stage I, 10 cases (28%) were stage II, 12 cases (32%) were stage III, 6 cases (16%) were stage IVA and 6 cases (16%) were stage IVB. Twenty-four cases (67%) displayed stage III or IV disease. The pathological types according to the WHO classification were as follows: B1 (32%), C (23%), B3 (20%), B2 (16%), AB (6%) and A (3%). Twenty-four patients underwent thymothymectomy and four of these patients relapsed. Stage III or type B3 was common in the relapsed patients. Five patientsexpired. Stage IV or type B3 and C were common in the expired patients. Conclusion: In this study, stage III or IV disease and type B3 or C were common at the time of diagnosis and these findings might contribute to postoperative recurrence and a poor outcome.


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