A Study on N-Arylation of Indole Using Copper Nitrate or Copper Carbonate as a Catalyst

Copper Nitrate와 Copper Carbonate를 촉매로 이용한 Indole의 N-Arylation 연구

  • Lee, Jun Young (Department of Chemical System Engineering, Keimyung University) ;
  • Yang, Min Ho (Department of Chemical System Engineering, Keimyung University) ;
  • Paik, Seung Uk (Department of Chemical System Engineering, Keimyung University)
  • 이준영 (계명대학교 공과대학 화학시스템공학과) ;
  • 양민호 (계명대학교 공과대학 화학시스템공학과) ;
  • 백승욱 (계명대학교 공과대학 화학시스템공학과)
  • Received : 2008.08.25
  • Accepted : 2008.09.27
  • Published : 2008.12.10


N-Arylation of indole with aryl iodides has been achieved by employing copper nitrate or copper cabonate as a catalyst, which might be more practical and economical over any other copper- or palladium-based catalysts for industrial applications. N,N'-dimethylethylenediamine was found to be the most effective with copper nitrate catalyst systems, while ethylenediamine was the most active with copper carbonate.

N-Arylation에 대한 경제적이고 실용적인 촉매시스템을 찾기 위하여 indole을 이용한 다양한 반응조건에서 실험이 수행되었으며, 결과적으로 본 연구에서 처음 시도한 copper nitrate와 copper cabonate가 다른 copper계 촉매나 palladium 촉매에 유사하거나 더 우수한 반응성을 보여주었다. Copper nitrate 촉매를 사용하는 경우에는 다양한 리간드 중에서 N,N'-dimethylethylenediamine 리간드가 더 효과적이었으며 copper cabonate 계에서는 ethylenediamine 리간드가 더 적합한 것으로 판명되었다.



Supported by : 계명대학교


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