Nano-capsulation of L-Ascorbic Acid in Nonaqueous System

L-Ascorbic Acid의 비수계 나노 캡슐화

  • Hong, Joo-Hee (Department of Chemical & Biochemical Engineering, Dongguk University) ;
  • Song, Ki-Se (Department of Chemical & Biochemical Engineering, Dongguk University) ;
  • Kim, Kyoung-Jun (Department of Chemical & Biochemical Engineering, Dongguk University) ;
  • Lee, Chae-Seong (Department of Chemical & Biochemical Engineering, Dongguk University) ;
  • An, Byeong-Min (Department of Chemical & Biochemical Engineering, Dongguk University) ;
  • Kim, Byoung-Sik (Department of Chemical & Biochemical Engineering, Dongguk University)
  • 홍주희 (동국대학교 화공.생물공학과) ;
  • 송기세 (동국대학교 화공.생물공학과) ;
  • 김경준 (동국대학교 화공.생물공학과) ;
  • 이채성 (동국대학교 화공.생물공학과) ;
  • 안병민 (동국대학교 화공.생물공학과) ;
  • 김병식 (동국대학교 화공.생물공학과)
  • Received : 2008.06.30
  • Accepted : 2008.10.16
  • Published : 2008.12.10

Abstract

In this work, the basic research for nano-capsulation of L-ascorbic acid (Vitamin C) in nonaqueous system was carried out. 500 nm-sized nano-capsules were prepared in nonaqueous system, and the emulsified capsule had mean size of 410 nm. The stability test on the temperature and the storage periods was performed at 4, 20, and $30^{\circ}C$ for 30 days. After 5 days, L-ascorbic acid was extricated 5.1, 9.3, and 12.5% at each temperature, but only 1~2 % was extricated after the time span. Likewise, the results of the skin susceptibility on women and men, each 10 persons, revealed that the very thin allergy was shown from only a woman after 2 days, but it was not shown from the others.

Keywords

L-ascorbic acid;Vitamin C;nano-capsulation;encapsulation;nonaqueous

Acknowledgement

Supported by : 산학협동재단

References

  1. J. D. Dziezak, Food Technology, 52, 136 (1998).
  2. S. K. Kanawjia, V. Pathania, and S. Singh. Indian Dairyman, 44, 280 (1992).
  3. G. O. Fanger, Microcapsulation processes and application, Plenum press, NY, (1974).
  4. A. Bossi, S. A. Piletsky, E. V. Piletska, P. G. Righetti, and A. Turner, Anal Chem., 2, 4296 (2007).
  5. H. Tsuchiya and C. J. Bates, J. Nurt. Biochem., 9, 402 (1998). https://doi.org/10.1016/S0955-2863(98)00039-4
  6. P. B. Deasy, Microencapsulation and related drug processes, Marcel Dekker. Inc., NY, (1984).
  7. L. S. Goodman and A. Gilman., As Bases Farmacologicas da Terapeutica, 9th Ed., McGraw Hill, (1996).
  8. L. J. Machlin, Handbook of Vitamins, 2nd Ed, Marcel Dekker, Inc., NY, (1991).
  9. B. Y. Ahn, J. H. Kim, S. I. Seok, S. Y. Ko, and H. K. Chang, J. Korean Ind. Eng. Chem., 13, 672 (2002).
  10. Y. Horino, S. Takahashi, T. Miura, and Y. Takahashi, Life Science, 71, 3031 (2002). https://doi.org/10.1016/S0024-3205(02)02142-2
  11. T. Doba, G. W. Burton, and K. U. Ingold, Biochim. Biophys. Acta, 835, 298 (1985). https://doi.org/10.1016/0005-2760(85)90285-1
  12. USP 5, 286, 495 (1994).
  13. USP 2, 556, 410 (1951).
  14. L. Yamamoto, A. Tai, Y. Fujinami, K. Sasaki, K. Okazaki, and S. J. Okazaki, Med. Chem., 45, 462 (2002). https://doi.org/10.1021/jm010379f
  15. F. Shahidi and X. Q. Han, Critical Reviews in Food Science and Nutrition, 33, 501 (1993). https://doi.org/10.1080/10408399309527645
  16. I. M. J. Hamilton, W. S. Gilmore, I. F. F. Benzie, C. W. Mulholland, and J. J. Strain, British Journal of Nutrition, 84, 261 (2000). https://doi.org/10.1017/S0007114500001537
  17. U. R. Pothakamury and G. V. Barbosa-Canovas, Trends in Food Science & Technology, 6, 397 (1995). https://doi.org/10.1016/S0924-2244(00)89218-3
  18. D. E. Pszczola, Food Technology, 52, 70 (1998).