The effects of Hagochosan(HGCS) on hyperlipidemia in rats induced by high cholesterol diet

하고초산(夏枯草散)이 고지혈(高脂血) 유발(誘發) SHR 백서(白鼠)에 미치는 영향(影響)

  • Yoo, Heon-Sook (Department of Oriental Pathology, College of Oriental Medicine, Daejeon University) ;
  • Choi, Hak-Joo (Department of Oriental Pathology, College of Oriental Medicine, Daejeon University) ;
  • Gim, Seon-Bin (Department of Oriental Pathology, College of Oriental Medicine, Daejeon University) ;
  • Kim, Dong-Hee (Department of Oriental Pathology, College of Oriental Medicine, Daejeon University)
  • 유헌숙 (대전대학교 한의과대학 병리학교실) ;
  • 최학주 (대전대학교 한의과대학 병리학교실) ;
  • 김선빈 (대전대학교 한의과대학 병리학교실) ;
  • 김동희 (대전대학교 한의과대학 병리학교실)
  • Published : 2008.12.31

Abstract

In order to investigate the effect of HGCS on Hypercholesterolemia in rats diagnosed with hypertension, changes of related factors in blood and tissues of animal models were studied. The results are as following: At 250 ${\mu}g/m{\ell}$ or lower doses of HGCS, human fibroblast cells showed a survival rate of more than 90%. HGCS significantly reduced the total cholesterol and LDL cholesterol levels in blood observed in hypercholesterolemia rats. On the other hand, HGCS signicantly increased the blood HDL cholesterol level, compared to that of the control group. HGCS significantly reduced triglycerides caused by hypercholesterolemia. However, glucose level was decreased insignificantly. Significant decrease of hyperoxidative lipid level in tissues due to hypercholesterolemia was observed in HGCS treated group. Significant increase of SOD and catalase activities in tissues due to hypercholesterolemia were observed in HGCS treated group. From the results above, the anti-hypercholesterolemic effect of clinically used HGCS has been experimentally proved. More active prescription of HGCS to hypercholesterolemia and related patients should be available in the future.