DOI QR코드

DOI QR Code

The Effects of Gastrodiae Rhizoma Powder on Plasma Lipid Profiles in the Elderly with Cardiovascular Disease

천마분말 복용이 심혈관계 질환 노인들의 혈중 지질 양상 변화에 미치는 영향

  • Yang, Kyung-Mi (Faculty of Cooking and Nutrition, Daegu Haany University)
  • 양경미 (대구한의대학교 한방식품조리영양학부)
  • Published : 2008.07.31

Abstract

This study was carried out to investigate the effects of Gastrodiae Rhizoma powder on plasma lipid profiles in elderly volunteers with hyperlipidemia, hypertension, diabetes or heart disease. 32 elderly people, 11 males and 21 females aged $60{\sim}77$ years, were given Gastrodiae Rhizoma powder 15 g twice daily for 6 months. We investigated the antheropometric data, general characteristics and dietary habit by using questionnaires. Fasting blood samples were collected from the subjects before and after this 6 months intervention study. Blood pressure, glucose, hemoglobin and lipid levels of plasma, atherogenic index (AI) and cardiac risk factors (CRF, LHR, HTR) were determined before and after consumption of Gastrodiae Rhizoma powder. The mean body mass index (BMI) of the male and female subjects were 22.4 and 23.6, respectively. The percent of ideal body weight (PIBW) of males and females were 105.6% and 122.3%, respectively. The subjects had decreased intake frequency of fish and meat in their dietary habit. After consumption of Gastrodiae Rhizoma powder, there were no significant differences in blood pressure; however, the blood glucose significantly decreased with Gastrodiae Rhizoma intake in the males. In the subjects, the levels of plasma total cholesterol, triglyceride, and LDL-cholesterol were decreased by the consumption of Gastrodiae Rhizoma powder; while the levels of plasma LDL-cholesterol was significantly decreased in female. Blood pressure and biochemical assessment (blood glucose, hemoglobin, triglyceride, total cholesterol, LDL and HDL-cholesterol) of the subjects were within the normal range. It was found that AI, CRF and LHR were significantly decreased by Gastrodiae Rhizoma intake. The present results indicate that dietary supplementation of Gastrodiae Rhizoma improved lipid metabolism and cardiac risk factor in cardiovascular disease.

References

  1. Kwon JS, Lee HJ. 2003. Nutritional and health status of the elderly living in Songnam-I. Antheropometric measurements and biochemical nutritional status. Kor J Food Nutr 16: 310-320
  2. Position of the American Dietetic association: nutrition, aging, and the continuum of care. 2000. J Am Diet Assoc 100: 580-595 https://doi.org/10.1016/S0002-8223(00)00177-2
  3. Martin N. 1992. Experimental cardiovascular depressant effect of garlic dialysate. J Ethnopharmacol 37: 145-153 https://doi.org/10.1016/0378-8741(92)90072-Y
  4. Park PS, Sung NJ, Park MY. 1999. Effects of Dioscorea batatas and Gastrodia rhizoma on lipid composition changes of liver, brain and kidney in rats. J East Asian Dietary Life 9: 188-194
  5. Choi YJ, Park YS, Kim C, Chang YK. 2004. Evaluation of functional ability and nutritional risk according to self-rated health (SRH) of the elderly in Seoul and Kyunggi-do. Kor J Nutr 37: 223-235
  6. Kim NJ, Jung EA, Kim DH, Lee SI. 1999. Studies on the development of antihyperlipidemic drugs from Oriental Herbal Medicines (I)-Antihyperlipidemic activities of Oriental herbal medicines-. Kor J Pharmacogn 30: 368-376
  7. 이상인, 박선동 공편저. 1998. 한방임상처방학. 도서출판 영림사, 서울. p 361-384
  8. Rhie SG, Park YJ. 1997. A study on nutrition education for rural elderly of Kyungki province in Korea. Kor Soc Community Living Sci 8: 25-33
  9. 유시용. 2004. 천연식물자원(한약재)으로부터 생리활성 물질의 탐색. 논문집 한의학편 4: 237-253
  10. Kim JK, Cha WS, Park JH, Oh SL, Cheon SH, Chung SK. 2004. Studies on the mineral component and antioxidative activity of Gastrodia elata Blum. Kor J Post-Harvest Sci Technol Agric Products 4: 317-321
  11. Han CK, Lee OK, Kim KI, Park JM, Kim YC, Lee BY. 2005. Effect of power, 50% ethanol and hot water extracts of Gastrodae Rhizoma on serum lipids and blood pressure in SHR fed high-fat diet. J Korean Soc Food Sci Nutr 32: 1095-1101
  12. Park PS, Park MY. 2001. Effects of Dioscorea batatas and Gastrodia on fatty acid compositions serum, liver and brain in rats. Kor J Life Sci 11: 83-92
  13. Yang CH, Kim MR, Kwen YZ. 2001. Effect of Gastrodiae rhizoma extract on plasma levels of electrolytes and aldosterone and plasma renin activity in unaneshtetized spontaneously hypertensive rats. J East-West Med 22: 1-22
  14. Heo JC, Park JY, An SM, Lee JM, Yun CY, Shin HM, Kwon TK, Lee SH. 2006. Anti-oxidant and anti-timor activities of crude extracts by Gastrodia elata Blume. Kor J Food Preserv 13: 83-87
  15. 허준. 1991. 동의보감. 남산당, 서울. p 367
  16. 중약대사전편찬위원회. 1997. 중약대사전. 정담출판사, 서울. p 4105-4110
  17. Kang JK, Moon SK, Ko CN, Cho KH, Kim YS, Bae HS, Lee KS. 1997. Experimental study on the effects of Chunma-Hwan on blood pressure and hyperlipidemia. KHM 13: 202-216
  18. Hong HD, Kim YC, Keum IK, Kim SS, Kim KI, Han CK. 2005. Effect of Gastrodiae rhizoma fractions on serum lipid concentrations in rats fed with high fat diet. J Korean Soc Appl Biol Chem 48: 370-374
  19. Kim AJ. 2004. The development and evaluation of a tool measuring Yangseng traditional oriental health promotion. PhD Dissertation. Ewha Woman's University
  20. Kim KN, Hyun TS, Lee JW. 2000. Development of a simple screening test for identifying Korean elderly at risk of undernutrition. Korean J Community Nutrition 5: 475-483
  21. Haglund O, Loustarinen R, Wallin R, Wibell I, Saldeen T. 1991. The effect of fish oil on triglycerides, cholesterol, fibrinogen and malondialdehyde in humans supplemented with vitamin. Eur J Nutr 121: 165-172 https://doi.org/10.1093/jn/121.2.165
  22. Friedwald WT, Levy RI, Fredireck DS. 1972. Estimation of the concentration of low density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Clin Chem 18: 499-502
  23. Bang MA, Cho YJ, Kim HA. 2002. Effect of Indongcho (L. japonica Thunb) on glucose and lipid metabolism and antioxidative enzyme system in streptozotocin-induced diabetic rats. Kor J Dietary Culture 17: 377-386
  24. McDowell I, Newell C. 1996. Measuring Health. 2nd ed. Oxford University Press
  25. Kang NE, Lee JY. 2005. The analysis of effect of nutrition education program for the elderly in Sung-nam area. Kor J Food Nutr 18: 357-366
  26. Yang IS, Lee JM, Sook CI. 1998. Nutrition knowledge and attitude analysis of elderly people for the development of nutrition education program. J Kor Dietetic Assoc 4: 76-87
  27. Yang IS, Lee JM, Chai IS, Yoon G. 1996. Foodservice management systems at elder-care sites for the improvement of elderly welfare politices in Korean. Kor J Nutr 29: 830-838
  28. Chung MS, Kang KJ. 1996. A survey on the health, food perceptions, and food habits of urban elderly men-With special reference to elderly men in the Tap-gol Park-. Kor J Dietary Culture 11: 455-463
  29. Yim KS, Min YH, Lee TY. 1997. Strategies to improve nutrition in the elderly: An analysis of health related factors and the nutritional risk index of the elderly. Kor J Community Nutr 2: 376-387
  30. Yim KS, Han MW, Kang YJ, Park HR, Kim CH. 2000. Analysis of dietary characteristics of participants attending the nutrition education program for hypertensive patients at a public health center. J Kor Dietetic Assoc 6: 125-135
  31. Han KH. 1999. Nutritional status and life style factors in elderly people. Kor J Comm Nutr 4: 279-298
  32. Yim KS, Lee TY. 2004. Sociodemographic factors associated with nutrients intake of elderly in Korea. Kor J Nutr 37: 210-222
  33. 모수미, 이연숙, 구재욕, 손숙미. 1997. 식사요법. 교문사, 서울. p 235
  34. Kwon JS, Lee HJ. 2003. Nutritional and health status of the elderly living in Songnam-I. Antheropometric measurements and biochemical nutritional status. Kor J Food & Nutr 16: 310-320
  35. Son HY, Cho KH. 1998. Health status of the elderly in Kwangju, Kyonggi-do by blood indices. Kor J Gerontol 8: 105-115
  36. Kim KI, Han CK, Seong KS, Lee OH, Park JM, Lee BY. 2003. Effect of whole power and extracts of Gastrodiae Rhizoma on serum lipids and body fat in rats fed high-fat diet Korean J Food Sci Technol 35: 720-725
  37. Sue JD. 1990. The risk factor of cardiovascular disease. Kor J Internal Med 38: 591-599
  38. Park YS. 1993. Community-base epidemiologic study on serum lipid profiles and their interaction with other atherosclerotic cardiovascular risk factors in Yonchon county. Kor Soc Lipidol Atheroscler 3: 272-279
  39. Castelli WP, Garrison RJ, Wilson PWF, Abborr RD, Kalousdian S, Kannel WB. 1986. Incidence of coronary heart disease and lipoprotein cholesterol levels. The Framingham study. JAMA 256: 2835-2845 https://doi.org/10.1001/jama.256.20.2835

Cited by

  1. The Quality Characteristics of Backsulgi Prepared with Yam(Dioscorea japonica) Powder vol.23, pp.1, 2012, https://doi.org/10.7856/kjcls.2012.23.1.031
  2. Effects of Gastrodiae rhizoma on the Liver Function and Alcohol Metabolism in Alcohol Treated Rats vol.32, pp.6, 2016, https://doi.org/10.9724/kfcs.2016.32.6.818
  3. A Study on Functional components, antioxidant activity of Gastrodiae Rhizoma and Gastrodiae Elata floral axis vol.30, pp.1, 2015, https://doi.org/10.6116/kjh.2015.30.1.19.