Bladder Volume Variations in Patients Receiving Conformal Radiotherapy to Prostate

전립선암 환자의 방사선 치료 시 방광 체적 변화

  • Lee, Re-Na (Department of Radiation Oncology, School of Medicine, Ewha Womans University) ;
  • Lee, Ji-Hye (Department of Radiation Oncology, School of Medicine, Ewha Womans University) ;
  • Lee, Kyung-Ja (Department of Radiation Oncology, School of Medicine, Ewha Womans University) ;
  • Ji, Young-Hoon (Laboratory of Radiation Medical Physics, Korea Institute of Radiological and Medical Sciences)
  • 이레나 (이화여자대학교 의학전문대학원 방사선종양학과) ;
  • 이지혜 (이화여자대학교 의학전문대학원 방사선종양학과) ;
  • 이경자 (이화여자대학교 의학전문대학원 방사선종양학과) ;
  • 지영훈 (원자력의학원 방사선 의학물리 연구팀)
  • Published : 2008.06.30

Abstract

Objective: To reduce urinary side effects in prostate cancer patients receiving radiation, patients were asked to drink certain amount of water to maintain bladder volume constant and the bladder volumes were measured weekly using ultrasound scanner. Materials and Methods: Twenty-six patients with prostate cancer who received radiation between December 2002 and August 2007 were enrolled in this study. Thirteen patients were enrolled in experimental group. These patients were asked to drink 450 cc of water, one hour prior to simulation, CT scan, and treatment. The other thirteen patients were given no information about bladder filing. Bladder, prostate, and rectum were contoured on CT and volumes were calculated. 3D conformal treatment planning was performed and effective volumes of bladder were calculated when a prescription dose of 70.2 Gy was delivered. For the patients in experimental group, bladder volumes were measured weekly using ultrasound scanner for 6-8 weeks and the bladder volume variations were analyzed. Results: Average bladder volumes and standard deviations obtained at CT scanning were $283.5{\pm}114.0\;cc$ (40%) and $181.2{\pm}120.1\;cc$ (66%) in experimental and control groups, respectively. Although it was not statistically significant, there was correlation between the bladder volumes measured from CT and ultrasound. The volumes measured using ultrasound scanner were 62% lower than the volumes using CT images on average. There was significant variations in volumes measured weekly for 6-8 weeks. It ranged between 33 - 75 %. Conclusion: Our results showed that it is possible to obtain larger bladder volume if they are asked to drink certain amount of water prior to CT scan. However, patients were unable to maintain constant bladder volumes over the 6-8 weeks of treatment period although they were asked to drink constant amount of water.

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