Analgesic and anti-inflammatory effect of the aqueous extract of Angelica dahurica

  • Choi, In-Ho (Department of Sasang Constitutional Medicine, College of Oriental Medicine, Semyung University) ;
  • Song, Yun-Kyung (Department of Sasang Constitutional Medicine, College of Oriental Medicine, Semyung University) ;
  • Lim, Hyung-Ho (Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Kyungwon University)
  • Published : 2008.06.30

Abstract

Background: Angelica dahurica has been used in various clinical cases. Its taste is hot and its property is warm, dry and nonpoisonous. Its efficacy is to remove wind-damp, cure swelling and edema, exhaust pus, stop itching, rhinitis and leukorrhea. Object: To test through experiment Angelica dahurica's analgesic and anti-inflammatory efficacy. Method: Inject acetic acid as a pain-inducing substance to the mice and measure visceral pain bywrithing reflex. Inject carrageenan that is an edema-inducing substance to the rat's paw and measure volume of edema. Take thermal pain to mice with plantar test and measure paw withdrawal latency. Normal group is non Angelica dahurica-treated group and treated group is Angelica dahurica-treated group. Results: In acetic acid-induced visceral model, treatment with Angelica dahurica suppressed writhing reflex significantlyand dose-dependently. In carrageenan-induced paw edema model, treatment with Angelica dahurica suppressed carrageenan-induced paw edema. In plantar test model, no significant effect on the withdrawal latency of thermal stimulation-induced nociception was observed. Conclusion: Angelica dahurica has analgesic and anti-inflammatory efficacy.