Detection of Helicobacter pylori in Saliva of Patient with Oral Lichen Planus

구강 편평태선 환자의 타액에서 Helicobacter pylori의 검출

  • Ryu, Ji-Won (Department of Oral Medicine, College of Dentistry, Chosun University) ;
  • Kang, Seung-Woo (Department of Oral Medicine, College of Dentistry, Chosun University) ;
  • Yoon, Chang-Lyuk (Department of Oral Medicine, College of Dentistry, Chosun University) ;
  • Ahn, Jong-Mo (Department of Oral Medicine, College of Dentistry, Chosun University)
  • 유지원 (조선대학교 치과대학 구강내과학교실) ;
  • 강승우 (조선대학교 치과대학 구강내과학교실) ;
  • 윤창륙 (조선대학교 치과대학 구강내과학교실) ;
  • 안종모 (조선대학교 치과대학 구강내과학교실)
  • Published : 2008.09.30

Abstract

Lichen planus is a common, chronic inflammatory disease of the skin and mucous membrane for which no precise causes have been confirmed. But it is often connected with infections. Helicobacter pylori(H. pylori) among various bacteria has been associated with the cause of gastritis, peptic ulcer and gastric cancer. Considering the similarities of histological features between gastric ulcer and oral ulcers, it is resonable to assume that H. pylori might also be involved in the development oral mucosal ulceration. So we employed this study to investigate the possible involvement of H. pylori in the aetiology of erosive oral lichen planus. We analyzed detection rate of H. pylori in saliva of patients with erosive oral lichen planus by nested PCR. As a result, it revealed a significant difference statistically by showing positivity in 16 to 21(76.2%) saliva samples of patients group and in 11 of 44(25%) saliva samples of control group(P>0.001). We were able to suppose that H. pylori in saliva can be related to cause of erosive oral lichen planus.

Keywords

Erosive oral lichen planus;Helicobacter pylori;saliva

References

  1. Czesnikiewicz-Guzik M, Karczewska E, Bielonski W. Association of the presence of Helicobacter pylori in the oral cavity and in the stomach. J Physiol Pharmacol 2004;15:187-194
  2. Sanli H, Cetinkaya H, Tursen U, Kaya M, Kuzu I, Gurler A. Upper gastrointestinal findings in oral lichen planus. Turk J Gastroentrol 2002;13(1):31-34
  3. Bussac G. Helicobacter pylori and the oral environment. Practical periodontics and aesthetic dentistiry 1999;11(8):918-922
  4. Leimola-Virtanen R, Happonen RP, Syrjanen S. Cytomegalovirus (CMV) and Helicobacter pylori (HP) found in oral mucosal ulcers. J Oral Pathol Med 1995;24(1):14-17 https://doi.org/10.1111/j.1600-0714.1995.tb01123.x
  5. Kang SW, Yoon CL, Ahn JM, Lee HJ, Hur W. Effect of vomiting in the intraoral incidence of Helicobacter pylori. Korean J Oral Med 2003;28(4):447-453
  6. Song Q, Spahr A, Schmid RM, Adler G, Bode G. Helicobacter pylori in the oral cavity : high prevalence and great DNA diversity. Dig Dis Sci 2000;45(11):2162-2167 https://doi.org/10.1023/A:1026636519241
  7. Riggio MP, Lennon A, Wray D. Detection of Helicobacter pylori DNA in recurrent aphthous stomatitis tissue by PCR. J Oral Pathol Med 2000;29(10):507-513 https://doi.org/10.1034/j.1600-0714.2000.291005.x
  8. Birek C, Grandhi R, McNeill K, Singer D, Ficarra G, Bowden G. Detection of Helicobacter pylori in oral pahthous ulcers. J Oral Pathol Med 1999;28(5):197-203 https://doi.org/10.1111/j.1600-0714.1999.tb02024.x
  9. Shimoyama T, Horie N, Kato T, Kaneko T, Komiyama K. Helicobacter pylori in oral ulceration. J Oral Sci 2000;42(4):225-229 https://doi.org/10.2334/josnusd.42.225
  10. Wotherspoon AC, Ortiz-Hidalgo C, Falzon MR, Lsaacson PG. Helicobacter pylori-associated gastritis and primary B-cell gastic lymphoma. Lancet 1991;338:1175-1176 https://doi.org/10.1016/0140-6736(91)92035-Z
  11. Andersen RN, Ganeshkumar N, Kolenbrander PE. Helicobacter pylori adheres selectively to Fusobacterium spp. Oral Microbiol Immunol 1998;13:51-54 https://doi.org/10.1111/j.1399-302X.1998.tb00751.x
  12. Tytgat GN, Noach LA, Rauwa EA. Helicobacter pylori infection and deuodenal ulcer disease. Gastroenterol Clin North Am 1993;22:127-139
  13. Veerman EC, Bank CN, Namavar F, Appelmelk BJ, Bolscher JG, Nieuw Amerongen AV. Sulfated glycans on oral mucin as receptors for Helicobacter pylori. Glycobiology 1997;7(6):737 -743 https://doi.org/10.1093/glycob/7.6.737
  14. Li C, Musich PR, Ha T et al. High prevalence of Helicobacter pylori in saliva demonstrated by a novel PCR assay. J Clin Pathol 1995;48(7):662-666 https://doi.org/10.1136/jcp.48.7.662
  15. Laskaris G. Color Atlas of Oral Disease. New York, 1988, Thieme Medical Publishers, Inc., pp.184-186
  16. Dauden E, Cabrero MM, Onate MJ, Pajares JM, Garcia-Dlez A. Helicobacter pylori Cag A seropositivity is not strongly associated with lichen planus. J Am Acad Dermatol 2003;49(6):1199
  17. Vainio E, Huovinen S, Liutu M, Uksila J, Leino R. Peptic ulcer and Helicobacter pylori in patients with lichen planus. Acta Derm Venereol 2000;80(6):427-429 https://doi.org/10.1080/000155500300012855
  18. Long BJ, Chen K, Wu BL, Duan JM. Detection of Helicobacter pylori in oral cavity of patients with recurrent aphthous ulcer. Nan Fang Yi Ke Da Xue Xue Bao 2007;27(4):477-478
  19. Westblom TU. Molecular diagnosis of Helicobacter pylori. Immunol Invest 1997;26:163-174 https://doi.org/10.3109/08820139709048924
  20. Dowsett SA, Kowolik MJ. Oral Helicobacter pylori : Can we stomach it ? Crit Rev Oral Biol Med 2003;14:226-233 https://doi.org/10.1177/154411130301400307
  21. Lamaroon A, Chaimano S, Linpisarn S, Pongsiriwet S, Phornphutkul K. Detection of Helicobacter pylori in recurrent aphthous ulceration by nested PCR. J Oral Sci 2003;45(2):107 -110 https://doi.org/10.2334/josnusd.45.107