Human Vesicular Glutamate Transporters Functionally Complement EAT-4 in C. elegans

  • Lee, Dukgyu (Department of Life Science, Gwangju Institute of Science and Technology) ;
  • Jung, Sunki (HCC R&D Center) ;
  • Ryu, Jungmin (HCC R&D Center) ;
  • Ahnn, Joohong (Department of Life Science, Gwangju Institute of Science and Technology) ;
  • Ha, Ilho (IBST/Graduate Program in Neuroscience, Inje University)
  • Received : 2007.05.02
  • Accepted : 2007.08.08
  • Published : 2008.02.29

Abstract

The vesicular glutamate transporter (VGLUT) transports glutamate into pre-synaptic vesicles. Three isoforms of VGLUT have been identified in humans, but their functional differences remain largely unknown. EAT-4 is the only homologue of human VGLUT in C. elegans. Here we report that mutants of eat-4 exhibit hyperforaging behavior and that each of the isoforms of human VGLUT functionally rescues the defects in eat-4 worms.

Keywords

C. elegans;eat-4;Foraging;Pharyngeal Pumping;VGLUT

Acknowledgement

Supported by : Inje University

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