Microbial Subversion of Heparan Sulfate Proteoglycans

  • Chen, Ye (Department of Digestive Diseases, Nanfang Hospital, Southern Medical University) ;
  • Gotte, Martin (Department of Gynecology and Obstetrics, Munster University Medical Center) ;
  • Liu, Jian (Division of Medicinal Chemistry and Natural Products, University of North Carolina) ;
  • Park, Pyong Woo (Division of Respiratory Diseases, Children's Hospital, Harvard Medical School)
  • Received : 2008.09.15
  • Accepted : 2008.09.18
  • Published : 2008.11.30


The interactions between the host and microbial pathogen largely dictate the onset, progression, and outcome of infectious diseases. Pathogens subvert host components to promote their pathogenesis and, among these, cell surface heparan sulfate proteoglycans are exploited by many pathogens for their initial attachment and subsequent cellular entry. The ability to interact with heparan sulfate proteoglycans is widespread among viruses, bacteria, and parasites. Certain pathogens also use heparan sulfate proteoglycans to evade host defense mechanisms. These findings suggest that heparan sulfate proteoglycans are critical in microbial pathogenesis, and that heparan sulfate proteoglycan-pathogen interactions are potential targets for novel prophylactic and therapeutic approaches.


adhesin;cellular entry;heparan sulfate;host defense;microbial pathogenesis;proteoglycan;syndecan;virulence factor


Supported by : National Institutes of Health


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