Single-minded 1 Gene Mapping and Its Variants Association with Growth, Carcass Composition and Meat Quality Traits in the Pig

  • Zhao, X.F. (College of Animal Science, Zhejiang University) ;
  • Xu, N.Y. (College of Animal Science, Zhejiang University) ;
  • Chen, Z. (College of Animal Science, Zhejiang University) ;
  • Wang, Q. (College of Animal Science, Zhejiang University) ;
  • Guo, X.L. (College of Animal Science, Zhejiang University)
  • Received : 2007.08.27
  • Accepted : 2008.02.27
  • Published : 2008.07.01


Single-minded 1 gene (SIM1) is a homolog of Drosophila SIM1 gene which plays a key role in the midline cell lineage of the central nervous system and is implicated in the regulation of feeding behavior and obesity in the human and mouse. In this study, porcine SIM1 gene was firstly mapped to chromosome 1p13 using radiation hybrid (RH) mapping and two polymorphisms were detected at position 607 (A/G) in SIM1 intron7 and position 780 (C/T) in SIM1 exon8. The last substitution was genotyped in a 364 F2 animal-population and an association analysis of these genotypes was performed with growth, carcass and meat quality traits by the statistical animal model. The results showed the significant influence of the SIM1 genotype on growth (p<0.05): live weight at birth, later period of growth and average daily gain; and effects on carcass composition (p<0.05): weight of head and buck kneed foreleg, backfat depth, loin eye area, carcass leaf fat and ham fat weights; and traits related to intramuscular fat content (p<0.05).


Prion Protein Genotypes;Scrapie;Goats;Pakistan


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