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CLIP-domain serine proteases in Drosophila innate immunity

  • Jang, In-Hwan ;
  • Nam, Hyuck-Jin ;
  • Lee, Won-Jae
  • Accepted : 2008.02.14
  • Published : 2008.02.29

Abstract

Extracellular proteases play an important role in a wide range of host physiological events, such as food digestion, extracellular matrix degradation, coagulation and immunity. Among the large extracellular protease family, serine proteases that contain a "paper clip"-like domain and are therefore referred to as CLIP-domain serine protease (clip-SP), have been found to be involved in unique biological processes, such as immunity and development. Despite the increasing amount of biochemical information available regarding the structure and function of clip-SPs, their in vivo physiological significance is not well known due to a lack of genetic studies. Recently, Drosophila has been shown to be a powerful genetic model system for the dissection of biological functions of the clip-SPs at the organism level. Here, the current knowledge regarding Drosophila clip-SPs has been summarized and future research directions to evaluate the role that clip-SPs play in Drosophila immunity are discussed.

Keywords

CLIP domain;Drosophila;Pro-phenoloxidase;Serine protease;Toll

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