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Effect of Korean Red Ginseng on Blood Pressure and Aortic Vascular(endothelial) Histological Changes in Rats

홍삼이 정상 흰쥐의 혈압 및 대동맥 조직 소견 변화에 미치는 영향

  • Joo, Il-Woo (Department of Family Medicine, Cheil General Hospital & Women's Healthcare Center, Kwandong University, College of Medicine) ;
  • Sung, Kyung-Hwa (Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Park, Jung-Min (Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Lew, Jae-Hwan (Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Oh, Han-Jin (Department of Family Medicine, Cheil General Hospital & Woen's Healthcare Center, Kwandong University, College of Medicine)
  • 주일우 (관동대 의과대학 제일병원 가정의학과) ;
  • 성경화 (경희대학교 동서의학대학원) ;
  • 박정민 (경희대학교 동서의학대학원) ;
  • 류재환 (경희대학교 동서의학대학원) ;
  • 오한진 (관동대 의과대학 제일병원 가정의학교실)
  • Published : 2008.12.31

Abstract

Introduction : Korean red ginseng has been shown to have an preventive effect on atheroma formation and enhancing effect on nitric oxide synthesis in endothelial cell inducing vasodilatation. However, there are few studies showing the effect of Korean red ginseng on blood pressure and vascular(endothelial) pathologic changes together. We designed this study to show changes of blood pressure and vascular pathologic findings with Korean red ginseng administration compared with Chinese red ginseng and control for 3 months in rats. Materials and methods : We studied the in vitro hypotensive effect and effect on vascular pathologic changes of Korean red ginseng compared with Chinese red ginseng and control. Rats were randomly assigned to three groups(Korean red ginseng, Chinese red ginseng and control) and evaluated by blood pressure and aortic vascular(endothelial) pathologic changes monthly during 3-month administration. All results were analyzed by paired T-test, ANOVA and post-hoc. Results : Blood pressure lowering effect was noted on Korean red ginseng and Chinese red ginseng compared to control. Especially, in Korean red ginseng group, hypotensive effect was showed in first and second month, but, in Chinese red ginseng group, it was just noted in first month. In case of vascular(aortic endothelial) pathologic finding, endothelial wall thickening and elastic fiber tearing were noted in Chinese red ginseng group compared with Korean red ginseng group and control with statistical significance.(p<0.05) Discussion : These results suggested Korean red ginseng could have more hypotensive effect and maintenance rather than Chinese red ginseng. And the difference of hypotensive effect between Korean red ginseng and Chinese red ginseng might has some association with difference of vascular pathologic findings in each group. However, further evaluation and research of other mechanism will be needed to convince this hypothesis.

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