Effect of Cheongpesagan-tang on the Change of Inhibitory Effect against Lipase Activity and Weight Loss, Plasma and UCP1, 2 mRNA Expression in db/db Mouse

태음인 청폐사간탕이 lipase 활성저해 및 db/db mouse의 체중감량, 혈장지질, UCP 1, 2 발현에 미치는 영향

  • Kim, Eun-Young (Dept. of Sasang Constitution Medicine, College of Oriental Medicine, Dongeui University) ;
  • Sul, Yu-Kyung (Dept. of Sasang Constitution Medicine, College of Oriental Medicine, Dongeui University) ;
  • Choi, Jae-Jung (Dept. of Sasang Constitution Medicine, College of Oriental Medicine, Dongeui University) ;
  • Jeon, Soo-Hyung (Dept. of Sasang Constitution Medicine, College of Oriental Medicine, Dongeui University) ;
  • Kim, Hoon (Dept. of Oriental Medical History, Dongeui University) ;
  • Kim, Jong-Won (Dept. of Sasang Constitution Medicine, College of Oriental Medicine, Dongeui University)
  • 김은영 (동의대학교 한의과대학 사상체질과) ;
  • 설유경 (동의대학교 한의과대학 사상체질과) ;
  • 최재중 (동의대학교 한의과대학 사상체질과) ;
  • 전수형 (동의대학교 한의과대학 사상체질과) ;
  • 김훈 (동의대학교 한의과대학 의사학교실) ;
  • 김종원 (동의대학교 한의과대학 사상체질과)
  • Published : 2007.04.30

Abstract

1. Objectvies This experimental study was designed to investigate the effect of cheongpesagan-tang extract on the obstruction of the lipase activity and weight, plasma, UCP1, 2 mRNA in db/db mouse. Material and Methods: The body weight loss, food intake, feeding efficiency ratio, weight of the internal organs (liver, kidney, epididymal fat, brown adipose tissue), plasma glucose, triglyceride, total cholesterol, white adipose tissue, adipocyte size distribution, expression of UCP1, 2 mRNA were measured in db/db mouse administered Cheongpesagan-tang extract for 6 weeks. These were then compared with those of control groups administered the diet. 2. Results 1) Inhibitory effect against lipase activity was Kilgyung(81.7%), Nabokja (73.1%), Seungma(73.0%), Daewhang (68.4%), Kalgeun (55.3%), Kobon(34.5%), Hwanggeum(4.2%). 2) In the sample group, the body weight was significantly decrease than that of control group. 3) In the sample group, the weight of epididymal fat showed significantly decrease than that of control group. 4) In the sample group, triglyceride showed significantly decrease than that of control group. 5) In the sample group, distribution of adipose tissue showed significantly larger than that of control group. 6) In the sample group, UCP1, 2 mRNA in BAT showed significantly increase than that of control group. 3. Conclusions These results show that cheongpesagan-tang has an effect on the treatment of obesity.