김해시 공업지역의 대기 중 Methylethylketone 측정과 활성산소종 생성에 관한 연구

Detection of Methylethylketone in the Ambient Air of Industrial Area in Gimhae City and Its Effect on the Generation of Reactive Oxygen Species

  • 박흥재 (인제대학교 환경공학부/생명환경연구소) ;
  • 정성욱 (인제대학교 환경공학부/생명환경연구소) ;
  • 김종명 (부경대학교 양식학과) ;
  • 안원근 (부산 대학교 나노메디컬 공학과)
  • Park, Heung-Jai (School of Environmental Science and Engineering/Bio- Environmental Institute, Inje University) ;
  • Jeong, Seong-Wook (School of Environmental Science and Engineering/Bio- Environmental Institute, Inje University) ;
  • Kim, Jong-Myoung (Department of Aquaculture, Pukyong National University) ;
  • An, Won-Gun (Department of Nanomedical Engineering, Pusan National University)
  • 발행 : 2007.08.31


This study assessed the characteristics of emission and cell toxicology of Methylethylketone(MEK) in ambient air of industrial area. MEK is produced by the oxidation of sec-butyl alcohol and used as the solvent for making ink, printing, coating of film, bonding material and drug extraction. The MEK concentrations in the ambient-air of industrial area in Gimhae City was detected in the range of $25.4{\sim}1,580{\mu}g/m^3$ with an average $297.4{\mu}g/m^3$. The concentration of MEK showed a descending tendency from April to August followed by its increased tendency since then. The effects of MEK on the human lung cancer A549 cells was examined by the generation of Reactive Oxygen Species(ROS) and cytotoxicity. The range of MEK concentration detected in the area induced ROS generation affecting the oxidation state with a little effects on the viability of the cells.


Methylethylketone(MEK);Reactive Oxygen Species(ROS);Cytotoxicity


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