Discovering cis-regulatory motifs by combining multiple predictors

  • Chang, Hye-Shik (Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology) ;
  • Hwang, Kyu-Woong (Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology) ;
  • Kim, Dong-Sup (Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology)
  • Published : 2007.06.30

Abstract

The computational discovery of transcription factor binding site is one of the important tools in the genetic and genomic analysis. Rough prediction of gene regulation network and finding possible co-regulated genes are typical applications of the technique. Countless motif-discovery algorithms have been proposed for the past years. However, there is no dominant algorithm yet. Each algorithm does not give enough accuracy without extensive information. In this paper, we explore the possibility of combining multiple algorithms for the one integrated result in order to improve the performance and the convenience of researchers. Moreover, we apply new high order information that is reorganized from the set of basis predictions to the final prediction.