Effect of Zingiber officinale Roscoe Fractionation of Extracts on Mouse Spleen and Macrophage Cells Activation

생강 분획에 따른 추출물이 마우스 비장세포와 Cytokine (IL-1 ${\beta}$, IL-6, TNF-${\alpha}$)의 생성량에 미치는 영향

  • 류혜숙 (상지대학교 보건과학대학 식품영양학과)
  • Published : 2007.06.30


Ginger(Zingiber officinale Roscoe) has long been used as a food source in Korea, and it is widely used as a dietary condiment throughout the world. The present study focused on the immunomodulative effects of ginger extracts via in vitro experiments. To identify the immune-activation fractions of the plant, we performed the systematic fractionation of ginger with methanol, hexane, chloroform, butanol and water for separation and refining. The results showed that the chloroform fraction had the highest immune cell activation properties. In conclusion, this study suggests that ginger extracts may enhance immune function by regulating the splenocyte proliferation as well as the cytokine production capacity of activated macrophages.


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