Abstract

In this study, uptake rates of internal organs and daily urinary excretion rates were measured to get more reliable estimation results for Korean. Radioactive iodine($^{131}I$) of $100{\mu}Ci$ was administered by ingestion to 28 adult males for the experiment and then the radioactivity in thyroid gland, liver, stomach, small intestine, kidneys, and urine was measured after time intervals of 2, 4, 6 and 24 hours. Uptake rates of each organ and daily urinary excretion rates were calculated on the basis of these experimental results. As a result, uptake rates of 19.70% for thyroid and daily urinary excretion rates of 71.12%, on the average, were indicated. The maximum of uptake rates and daily urinary excretion rates were recorded after 2 hours of administration of $^{131}I$, but those rates were decreased gradually later. It was also found that uptake rates were the highest in stomach, followed by the left kidney, liver, small intestine and right kidney except for thyroid gland. In this experiment, the calculated uptake change rate in thyroid gland after 24 hours of administration of $^{131}I$ was different from that of ICRP-54/67(30%) and ICRP-78(25%). Thus, it is necessary to apply more reliable approach, reflecting the characteristic of Korean physiology and to obtain the basic data of results using this approach for calculation of the internal adsorbed dose. In the future, this approach can be helpful for the internal dose assessment of radiation workers in a nuclear power plant or in a hospital.

Keywords

• Internal absorbed dose;
• Thyroid uptake;
• Urinal excretion;
• $^{131}I$

• 체내 흡수선량;
• 갑상선 잔류율;
• 소변 일일배설률;

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References

1. 고창순, 핵의학. 서울;고려의학, 1997;246-251
2. Loevinger R, Budinger TF, Watson EE, MIRD Primer for Absorbed Dose Calculations. The Society of Nuclear Medicine. 1991;1-18
3. Stabin MG, Tagesson M, Thomas SR, Ljungberg M, Strand SE, Radiation dosimetry in nuclear medicine. Applied Radiation and Isotopes. 1999;50: 73-87 https://doi.org/10.1016/S0969-8043(98)00023-2
4. Zanzonico PB, Internal Radionuclide Radiation Dosimetry: A Review of Basic Concepts and Recent Developments. J. Nucl. Med, 2000;41:297-308
5. Jeffry AS, Stephen RT, James BS, Stabin MG, Marguerite TH, Kenneth FK, James S R, Roger WH, Barry WW, Darrell RF, David AW, MIRD Pamphlet No. 16: Techniques for Quantitative Radiopharmaceutical Biodistribution Data Acquisition and Analysis for Use in Human Radiation Dose Estimates. J. Nucl. Med, 1999;37S-61S
6. International Commission on Radiological Protection, Individual Monitoring for Intakes of Radionuclides by Workers: Design and Interpretation. Oxford: Pergamon Press; ICRP Publication 54. 1987;141-154
7. International Commission on Radiological Protection. Age-dependent doses to members of the public from intake of radionuclides: Part2 Ingestion dose coefficients Oxford: Pergamon Press; ICRP Publication 67. 1993;141-167
8. International Commission on Radiological Protection. IndividualMonitoring for Internal Exposure of Workers. Oxfrod: Pergamon Press: Replacement of ICRP Publication 54 ICRP Publication 78. 1997;74-84
9. Edward T, Yihua X, Skrable KW, Chabot GE, French CS, Labone TR, Johnson JR, Fisher DR, Belanger R, Lipsztein JL, Interpretation of Bioassay Measurements: NUREG/CR- 4884, BNL- NUREG-52063, Washington. DC, 1987;22- 33
10. Ham GJ, Hodgson SA, Youngman MJ, Etherington G, Stradling GN, Review of Autopsy in Vivo and Bioassay Measurements on Members of the Public in the UK. NRPB -W42, National Radiological Protection Board, 2003;44- 46
11. George AT, The Evolution of Internal Dosimetry Bioassay Methods at the Savannah River Site. WSRC-MS-2000- 00290, Oak Ridge National Laboratory, Oak Ridge, TN, USA. 2000;1-13