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Effects of a Porcine MC4R Polymorphism(892G>A) on Carcass Traits in Commercial Pigs

돼지 MC4R 유전자 892G>A 다형성이 비육돈의 도체형질에 미치는 영향

  • Han, S.H. (National Institute of Subtropical Agriculture, RDA) ;
  • Lee, S.S. (National Institute of Subtropical Agriculture, RDA) ;
  • Ko, M.S. (National Institute of Subtropical Agriculture, RDA) ;
  • Seong, P.N. (National Institute of Animal Science, RDA) ;
  • Park, B.Y. (National Institute of Animal Science, RDA) ;
  • Cho, I.C. (National Institute of Subtropical Agriculture, RDA)
  • 한상현 (농촌진흥청 난지농업연구소) ;
  • 이성수 (농촌진흥청 난지농업연구소) ;
  • 고문석 (농촌진흥청 난지농업연구소) ;
  • 성필남 (농촌진흥청 축산과학원) ;
  • 박범영 (농촌진흥청 축산과학원) ;
  • 조인철 (농촌진흥청 난지농업연구소)
  • Published : 2007.10.31

Abstract

receptor(MC4R) gene and carcass traits was examined in randomly selected commercial pigs. A porcine MC4R gene was genotyped for Asp298Asn(nt. 892G>A) by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP). A total of three genotypes, A/A, A/G, and G/G, were found with 28.8, 22.8, and 48.4% frequencies, respectively. In the whole population, pigs containing 892A/- showed significantly higher marbling score than those of homozygotes G/G(P<0.05). Two homozygotes, A/A and G/G showed lower in meat color score but higher in water holding capacity than those of heterozygotes A/G(P<0.01). However, the carcass weight of the barrows containing wild type -/G was significantly higher(i.e. more than 2.5kg) than those of homozygotes A/A(P<0.05). The effects of each genotype on carcass traits in the gilts were similar to those of the whole population, but not in barrows, suggesting an unknown sex-related effect on carcass traits. This study suggested that the genotype MC4R A/- could improve the meat quality in the commercial pig production. However, since the genetic polymorphism of MC4R gene differentially affected the carcass traits in sex-related manner, therefore, both parameters, the sex and genotype, should be considered for marker-assisted selection in commercial pig production.

Keywords

Association;MC4R;Genotype;Mutation;Sex-related manner;Pig

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  1. Characterization and Evaluation of Melanocortin 4 Receptor (MC4R) Gene Effect on Pork Quality Traits in Pigs vol.54, pp.1, 2012, https://doi.org/10.5187/JAST.2012.54.1.1