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Conjugated Linoleic Acid(CLA)가 돼지 지방세포와 근육세포의 증식과 분화에 미치는 영향

Effect of Conjugated Linoleic Acid(CLA) on Proliferation and Differentiation of Porcine Adipocyte and Muscle Cell

  • 정정수 (충북대학교 농업생명환경대학 축산학과) ;
  • 김혜림 (충북대학교 농업생명환경대학 축산학과) ;
  • 강지나 (충북대학교 농업생명환경대학 축산학과) ;
  • 김내수 (충북대학교 농업생명환경대학 축산학과)
  • Chung, C.S. (Department of Animal Science, Chungbuk National University) ;
  • Kim, H.R. (Department of Animal Science, Chungbuk National University) ;
  • Kang, J.N. (Department of Animal Science, Chungbuk National University) ;
  • Kim, N.S. (Department of Animal Science, Chungbuk National University)
  • 발행 : 2007.02.28

초록

본 연구는 여러 CLA 이성체, 즉 cis-9, cis- 11(c9c11), cis-9, trans-11(c9t11), trans-9, trans-11 (t9t11) 및 trans-10, cis-12(t10c12)가 배양 중인 돼지 지방세포와 근육세포의 분화와 증식에 미치는 영향을 구명하고자 실시하였다. 세포는 신생자돈으로부터 분리했다. t10c12 이성체는 지방세포의 분화를 억제했는데(92%) 근육세포의 분화는 억제시키지 않았다. t9t11 이성체는 지방세포의 분화를 억제했는데(14%), 근육세포의 분화는 촉진시켰다(26%). 다른 CLA 이성체는 지방세포나 근육세포의 분화에 영향을 미치지 않았다. 그리고 CLA가 지방세포와 근육세포의 증식에 미치는 영향은 분화에 미치는 영향에 비해서 작았다. 위의 결과는 여러 CLA 이성체는 돼지 지방세포와 근육세포의 분화에 다른 영향을 미침을 나타낸다.

키워드

CLA;Pig;Preadipocyte;Myogenic satellite cells;Differentiation

참고문헌

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