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Effect of Conjugated Linoleic Acid(CLA) on Proliferation and Differentiation of Porcine Adipocyte and Muscle Cell

Conjugated Linoleic Acid(CLA)가 돼지 지방세포와 근육세포의 증식과 분화에 미치는 영향

  • Chung, C.S. (Department of Animal Science, Chungbuk National University) ;
  • Kim, H.R. (Department of Animal Science, Chungbuk National University) ;
  • Kang, J.N. (Department of Animal Science, Chungbuk National University) ;
  • Kim, N.S. (Department of Animal Science, Chungbuk National University)
  • 정정수 (충북대학교 농업생명환경대학 축산학과) ;
  • 김혜림 (충북대학교 농업생명환경대학 축산학과) ;
  • 강지나 (충북대학교 농업생명환경대학 축산학과) ;
  • 김내수 (충북대학교 농업생명환경대학 축산학과)
  • Published : 2007.02.28

Abstract

The current study was undertaken to determine the effect of conjugated linoleic acid(CLA) isomers, cis-9, cis-11(c9c11), cis-9, trans-11(c9t11), trans-9, trans-11(t9t11), trans-10, cis-12(t10c12) on differentiation of pig preadipocytes and myogenic satellite cells during culture. Cells were isolated from new born pigs. The t10c12 isomer decreased differentiation of pig preadipocytes(92%), but not that of myogenic cells. The t9t11 isomer decreased differentiation of preadipocytes(14%) and increased that of myogenic cells (26%). No other CLA isomers affected differentiation of preadipocytes or myogenic cells. The effects of CLA on proliferation of preadipocytes and myogenic cells were small, compared to the effects on differentiation. These results suggest that CLA isomers have different effects on differentiaton of pig preadipocytes and myogenic cells.

Keywords

CLA;Pig;Preadipocyte;Myogenic satellite cells;Differentiation

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