Molecular and Cellular Mechanisms of Syndecans in Tissue Injury and Inflammation

  • Bartlett, Allison H. (Department of Pediatrics, Baylor College of Medicine) ;
  • Hayashida, Kazutaka (Department of Medicine, Baylor College of Medicine) ;
  • Park, Pyong Woo (Department of Medicine, Baylor College of Medicine)
  • Received : 2007.09.22
  • Accepted : 2007.09.24
  • Published : 2007.10.31


The syndecan family of heparan sulfate proteoglycans is expressed on the surface of all adherent cells. Syndecans interact with a wide variety of molecules, including growth factors, cytokines, proteinases, adhesion receptors and extracellular matrix components, through their heparan sulfate chains. Recent studies indicate that these interactions not only regulate key events in development and homeostasis, but also key mechanisms of the host inflammatory response. This review will focus on the molecular and cellular aspects of how syndecans modulate tissue injury and inflammation, and how syndecans affect the outcome of inflammatory diseases in vivo.


Supported by : GlaxoSmith-Kline, Mizutani Foundation Research, National Institutes of Health


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