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The Effect of Apolipoprotein E Polymorphism on Hypertension in Korean Adults

고혈압과 apolipoprotein E의 다형성

  • Choi, Dae-Kyung (Department of Preventive Medicine, Gachon Medical School) ;
  • Kim, Geum-Ha (Department of Internal Medicine, Gachon Medical School) ;
  • Park, Sang-Hyun (Department of Anesthesiology and Pain Medicine, Cheju National University School of Medicine) ;
  • Im, Jeong-Soo (Department of Preventive Medicine, Gachon Medical School)
  • 최대경 (가천의학전문대학원 예방의학과) ;
  • 김금하 (가천의학전문대학원 내과) ;
  • 박상현 (제주대학교 의과대학 마취통증의학과) ;
  • 임정수 (가천의학전문대학원 예방의학과)
  • Published : 2007.09.30

Abstract

Background: Apolipoprotein E has been one of the most thoroughly studied genetic polymorphisms, particularly for its effects on lipid profiles and coronary heart disease risk. This study investigated the relationship between the apolipoprotein E polymorphism and essential hypertension in a Korean population. Methods: The subjects (n=1,243) were participants in a population-based study in Incheon metropolitan City, Korea. The apolipoprotein E polymorphism was determined using a polymerase chain reaction method. Results: The frequencies of the genotypes did not differ significantly between the hypertensive groups (60.0% ε2 / ε2, 30.8% ε2 / ε3, 44.4% ε2 / ε4, 33.3% ε3 / ε3, 32.3% ε3 / ε4, and 15.4% ε4 / ε4; p=0.498). After adjusting for other risk factors, genotypes were not associated with hypertension(OR 5.74, 95% CI 0.81-40.76, ε2 / ε2 vs. ε3 / ε3; OR 0.94, 95% CI 0.60-1.47, ε2 / ε3 vs. ε3 / ε3; OR 1.21, 95% CI 0.30-4.89, ε2 / ε4 vs. ε3 / ε3; OR 0.79, 95% CI 0.56-1.13, ε3 / ε4 vs. ε3 / ε3; OR 0.29, 95% CI 0.06-1.45, ε4 / ε4 vs. ε3 / ε3). Conclusions: These findings suggest that the apolipoprotein E polymorphism is not associated with hypertension.

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