Preparation and Characterization of EGCG Entrapped Ethosome

EGCG가 포집된 Ethosome의 제조와 특성조사

  • Gwak, Hyo Jung (Department of Applied Chemistry, Dongduk Women's University) ;
  • Jin, Byung Suk (Department of Applied Chemistry, Dongduk Women's University)
  • 곽효정 (동덕여자대학교 응용화학과) ;
  • 진병석 (동덕여자대학교 응용화학과)
  • Received : 2007.01.29
  • Accepted : 2007.02.15
  • Published : 2007.04.10

Abstract

Entrapment of (-)-epigallocatechin gallate (EGCG) into ethosome was carried out for improving its stability against decomposition. Solubility of EGCG was increased by the addition of ethanol into water, which enable ethosome to entrap appropriate amount of EGCG. It was observed that the EGCG solution concentration and constituent lipid composition had a considerable effect on the particle size and entrapment efficiency of ethosomes. The formation of liquid crystalline phase in ethosome was investigated by polarized optical microscopy. By comparing the stability of EGCG in solution and in ethosome exposed to UV or high temperature, we evaluated the EGCG stabilization effect through its entrapment in ethosome. Incorporation of tocopherol into ethosome retarded the decomposition of EGCG under UV.

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