Efficient Synthesis of 1,3-Thiazole Derivatives from Arylidenethiosemicarbazones in the Presence of β-Cyclodextrin with Water

수용액과 β-Cyclodextrin 하에서 Arylidenethiosemicarbazone들로부터 1,3-Thiazole 유도체들의 효율적 합성

  • Park, Kyung-Jin (Department of Chemistry, Kunsan National University) ;
  • Bae, Sun Kun (Department of Chemistry, Kunsan National University)
  • 박경진 (군산대학교 화학과) ;
  • 배선건 (군산대학교 화학과)
  • Received : 2007.04.23
  • Accepted : 2007.06.20
  • Published : 2007.08.10

Abstract

2-Arylidenehydrazinyl-4-arylthiazole derivatives (9a-f) were prepared by the in situ formation of ${\beta}$-cyclodextrin complex of 2,4'-dibromoacetophenone (8) in water followed by the addition of arylidenethiosemicarbazones (7a-f) in 70~88% yield. The structures of the compounds 9a-f were elucidated by IR and $^1H-NMR$ spectral data. The role of ${\beta}$-cyclodextrin appears to activate the compound 7 and 8 and promote the reaction to complete in reduced reaction time.

Keywords

1,3-thiazole;complex;arylidenethiosemicarbazone;2,4'-dibromoacetophenone;${\beta}$-cyclodextrin

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