Establishment acceptable daily intakes(ADIs) for pesticides registered in Korea

국내등록농약의 일일섭취허용량(ADI) 설정

  • Lee, Je-Bong (National Institute of Agricultural Science and Technology) ;
  • Shin, Jin-Sup (National Institute of Agricultural Science and Technology) ;
  • Park, Yeon-Ki (National Institute of Agricultural Science and Technology) ;
  • You, Are-Sun (National Institute of Agricultural Science and Technology) ;
  • Hong, Soon-Sung (National Institute of Agricultural Science and Technology) ;
  • Im, Gun-Jae (National Institute of Agricultural Science and Technology) ;
  • Kang, Kyu-Young (Dept. of Environ. Biotechnology, Gyeong Sang National University)
  • 이제봉 (농촌진흥청 농업과학기술원) ;
  • 신진섭 (농촌진흥청 농업과학기술원) ;
  • 박연기 (농촌진흥청 농업과학기술원) ;
  • 유아선 (농촌진흥청 농업과학기술원) ;
  • 홍순성 (농촌진흥청 농업과학기술원) ;
  • 임건재 (농촌진흥청 농업과학기술원) ;
  • 강규영 (경상대학교 환경생명화학과)
  • Published : 2007.12.30

Abstract

In order to set ADIs for pesticides registered for use in Korea, an analysis of guidelines on setting ADIs and ADIs established by international bodies and advanced countries was conducted General guidelines on the derivation ADIs are very similar among regulatory authorities. However, there were large differences in the ADIs' setting status and ADI values set for some individual pesticides. ADIs were established for 213 pesticides in UN, 332 in USA, 230 in Japan, 219 in UK and 435 in EU and Australia. Of the established ADIs in other countries, 87 to 252 pesticides were the pesticides registered in Korea depending countries. The number of lowest ADIs depending countries was 32 in USA, 23 in Japan, 6 in EU and Australia. The key target organs and endpoints used for setting ADIs were in the order of enzyme inhibition, body weight change and adverse effect on liver. The number of ADIs used for setting MRLs in Korea was high in the order of JMPR, Japan and USA. ADIs of EU and JMPR had highest similarity among bodies investigated. By referring to the guidances investigated at this study, guideline for setting ADI and ADIs for 64 pesticides registered in Korea were proposed.

Keywords

Pesticide;Risk assessment;ADI

References

  1. Edward G. III., L. B. Karen, and M. B. Charles (2000) Comparison of U.S. EPA and JMPR safety standards for pesticides, as of June 2000
  2. IPCS/lNCHEM (2002) JMPR monographs and evaluation : http://www.inchem.org/pages/jmpr.html
  3. UK PSD(ACP) (2003) A guide to pesticide regulation in the UK and the role of the advisory committee on pesticide
  4. US EPA (2004) Acute and Chronic Reference Dose
  5. US EPA (2004) Guidance for Hazard Identification and Toxicity Endpoint Selection
  6. 농업과학기술원 (2006) EU 국가의 농약안전성 평가관리기법 연구
  7. Europa (2007) From the farm to the fork-status of active substances under the EU review. http://ec.europa.eu/food/plant/protection/pesticides/index_en.htm
  8. WHO/IPCS (2002) Inventory of IPCS and other WHO pesticide evaluations and summary of toxicological evaluations performed by the Joint Meeting on Pesticides Residues(JMPR) through 2002
  9. Japan/ Food Safety Commission (2007) http://www.fsc.go.jp/hyouka/ hy_nouyaku.html
  10. 한국과학기술연구원과 한국산업기술진흥협회 (2000) 진보된 안전성 평가와 환경호르몬 검출기법
  11. US EPA (2002) A review of the reference dose and reference concentration processes
  12. 농림부 (2005) 농약안전사용 실무교육
  13. Andrew G. R. (2002) Pesticide residue analysis and its relationship to hazard characterization(ADI/ARfD) and intake estimations(NEDI/NESTI), Pest Manag Sci 58 : 1073-1082 https://doi.org/10.1002/ps.544
  14. 농업과학기술원 (2001-2005) 농약안전성심위위원회 소위원회 자료
  15. United Nation (2005) Globally harmonized system of classification and labelling of chemicals(GHS)
  16. US EPA (2002) Determination of the appropriate FQPA safety factor(s) in tolerance assessment
  17. UK/PSD (2007) Mnograph : http://www.pesticides.gov.uk/psd_evaluation_all.asp