Synthesis of Dimeric Oligodeoxyribonucleotide

이합체성 올리고디옥시리보핵산의 합성

  • 송정섭 (선문대학교 화학과/자연과학연구소)
  • Published : 2007.12.31


Oligodeoxyribonucleotide bearing the di-acetylenic linkage has been prepared. Staring from 5-Iodo-2'-deoxyuridine(1), a four-step sequence, consisting of the Pd(0)-catalyzed Heck-type C-C coupling with acetylenic group, protection of 5'-hydroxy group, generation of acetylenic hydrogen, and Glaser oxidative coupling reaction leads to the dimeric oligodeoxyribonucleotide(5).