The Effect of Menstration on GnRH Agonist Treatment for the Uterine Myoma

자궁근종의 성선자극호르몬분비호르몬 효능제 치료에 있어 생리의 영향

  • Han, Soo-Kyung (Department of Pharmacy, Chungnam National University Hospital) ;
  • Lee, Myung-Koo (College of Pharmacy, Chungbuk National University) ;
  • Han, Song-Yi (College of Pharmacy, Chungbuk National University) ;
  • Park, Mi-Sook (Department of Pharmacy, Chungnam National University Hospital) ;
  • Lim, Sung-Cil (College of Pharmacy, Chungbuk National University)
  • Published : 2007.12.31


The aim of this study was to evaluate the effect of menstration among the influencing factors for the GnRH agonist (as G: depot goserelin 3.6 mg) therapy prior to the planned myomectomy for women who wanted to preserve their fertility. We reviewed total 48 patients. with the G therapy prior to the planned myomectomy from August 1st, 2005 to August 31st, 2006. The patients were classified by the G group (n=28) and the immediate surgery (as S) group (n=20). The G group (n=19) underwent the G therapy for 3 month courses, and then the efficacy was evaluated by menstruation and the myoma volumes. In the G group (n=19), therapy was effective, and the mean age was $32.4{\pm}6.5$ years. After the completion of G therapy, the mean volume of the myoma by ultrasonography was reduced to $85.2{\pm}71.2cm^3$ comparing of $430.6{\pm}248.8cm^3$ at first visit. The 11 patients had menstruation and the rest 8 patients with amenorrhea had less reduced volume of the myoma ($124.05{\pm}79.85cm^3\;v.s.\;329.41{\pm}234.0cm^3$ p<0.05). In the immediate S group, the myoma volumes by sonography was also checked for accuracy (${\alpha}=1.0$). As the result, the initial myoma volume had the positive correlations to the effectiveness with G therapy. However, the occurrence and frequency of the menstruation during the G therapy had a negative correlation. In conclusion, the use of G prior to the planned myomectomy was effective in reducing myoma volume and the menstruation.


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