Measurement of Growth Delay and the Oxygen Enhancement Ratio of Fast Neutron Beam Using Mouse Model System

마우스모델을 이용한 고속중성자선의 성장지연 및 산소증강비의 측정

  • Eom, Keun-Yong (Department of Radiation Oncology, Seoul National University College of Medicine) ;
  • Park, Hye-Jin (Department of Radiation Oncology, Seoul National University College of Medicine) ;
  • Kwon, Eun-Kyung (Department of Radiation Oncology, Seoul National University College of Medicine) ;
  • Ye, Sung-Joon (Department of Radiation Oncology, Seoul National University College of Medicine) ;
  • Lee, Dong-Han (Department of Radiation Oncology, the Korea Institute of Radiological and Medical Sciences) ;
  • Wu, Hong-Gyun (Department of Radiation Oncology, Seoul National University College of Medicine)
  • 엄근용 (서울대학교 의과대학 방사선종양학교실) ;
  • 박혜진 (서울대학교 의과대학 방사선종양학교실) ;
  • 권은경 (서울대학교 의과대학 방사선종양학교실) ;
  • 예성준 (서울대학교 의과대학 방사선종양학교실) ;
  • 이동한 (원자력의학원 방사선종양학과) ;
  • 우홍균 (서울대학교 의과대학 방사선종양학교실)
  • Published : 2007.12.30

Abstract

Neutrons are high LET (linear energy transfer) radiation and cause more damage to the target cells than x-rays or gamma rays. The damage from neutrons is generally considered fatal to a cell and neutrons have a greater tendency to cause cell death through direct interaction on DNA. We performed experiments to measure growth delay ratio and oxygen enhancement ratio (OER) in mouse model system. We inoculated EMT-6 cells to the right hind leg of BALB-c mouse and X-rays and neutron beams were given when the average volume of tumors reached $200-300mm^3$. We irradiated 0, 11, 15.4 Gy of X-ray and 0, 5, 7 Gy of fast neutron beam at normoxic and hypoxic condition. The volume of tumors was measured 3 times per week. In x-ray experiment, growth delay ratio was 1.34 with 11 Gy and 1.33 with 15.4 Gy in normoxic condition compared to in hypoxic condition, respectively. In neutron experiment, growth delay ratio was 0.94 with 5 Gy and 0.98 with 7 Gy, respectively. The OER of neutron beam was 0.97. The neutron beam was more effective than X-ray in the control of hypoxic tumors.

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