RADIOPROTECTIVE EFFECT OF ALGIN-OLIGOSACCHARIDE THROUGH MEASURING CASPASE-3 AND CASPASE-9 IN MICE

  • Choi, Seong-Kwan (Dept. of Radiological Science, Hanlyo University) ;
  • Jung, Woon-Kwan (Dept. of Nuclear Energy Technology, Chosun University) ;
  • Lee, Kyu-Soo (Dept. of Radiological Science, Hanlyo University) ;
  • Jang, Young-Il (Dept. of Radiological Technology, Kwangysng Health College) ;
  • Dong, Kyeong-Rae (Dept. of Radiological Technology, Kwangysng Health College)
  • Published : 2007.12.30

Abstract

In order to find out the Radioprotective effect of algin-oligosaccharide(AOS), this study, with a mouse of which whole frame irradiated by 3 Gy radiation once, measured caspase-3 and caspase-9 amid cell signaling connected to apoptosis in order to observe cell activation. In Caspase-3 and Caspase-9 test for observing cell activation, both of Caspase-3 and Caspase-9 showed highly increased O.D. value in the irradiation control group, while the whole groups treated with algin-oligosaccharide before or after irradiation indicated lower O.D. value than the irradiation control group, especially showed big difference in 7 day's treatment group of before irradiation (P<0.001). It confirmed that Caspase generation was restrained in AOS treatment group. Consequently, this study inquired into the fact that algin-oligosaccharide with superior antioxidant activity performed radiation protection by inducing restraint of Caspase generation and confirmed that natural product with less chemical toxicity was able to be applied as radioprotector.

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