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Growth Inhibition of Helicobacter pylori by Ingestion of Fermented Soybean Paste

된장 섭취에 의한 Helicobacter pylori의 생장 억제

  • Published : 2007.12.30

Abstract

The aim of this study was to estimate the ingestion effect of fermented soybean paste on the growth inhibition of Helicobacter pylori. Anti-H. pylori effect of the aqueous extract of soybean paste and cell-free supernatant of the isolates from soybean paste were determined using agar diffusion method. Soybean paste and the isolates inhibited the growth of H. pylori. Effect of soybean paste ingestion was estimated using urea breath test against infected volunteers showing no symptom of gastric disease. When 10 g of soybean paste was ingested 3 times a day for 6 weeks, average value of $P={\Delta}^{13}C(T_1-T_0)$ decreased from P=58 to P=28. This result indicated that fermented soybean paste was effective to inhibit the growth of H. pylori in gastric tissue.

References

  1. Ahn, Y. O. 1997. Diet and stomach cancer in Korea. Int. J. Cancer Suppl. 10, 7-9
  2. Baik, S. C., J. B. Kim, M. J. Cho, Y. C. Kim, C. K. Park, H. H. Ryou, H. J. Choi and K. H. Rhee. 1990. Prevalence of Helicobacter pylori infection among normal Korean adult. J. Kor. Soc. Microbiol. 25, 455-462
  3. Brenner, H., D. Rothenbacher, G. Bode and G. Adler. 1999. Inverse graded relation between alcohol consumption and active infection with Helicobacter pylori. Am. J. Epidemiol. 149, 571-576 https://doi.org/10.1093/oxfordjournals.aje.a009854
  4. Chung, Y. S., K. H. Kang and M. W. Chang. 2001. Effects of green and taste teas on the growth and vacuolating toxin titer of Helicobacter pylori. Kor. J. Biotechnol. Bioeng. 16, 163-169
  5. Correa, P., E. T. Fontham, J. C. Bravo, L. E. Bravo, B. Ruiz, G. Zarama, J. L. Realpe, G. T. Malcom, D. Li, W. D. Johnson and R. Mera. 2000. Chemoprevention of gastric dysplasia: randomized trial antioxidant supplements and anti-Helicobacter pylori therapy. J. Nat. Cancer Inst. 92, 1881-1888 https://doi.org/10.1093/jnci/92.23.1881
  6. Eum, B. W., B. Y. Kwak, S. Y. Kim, D. H. Shon and K. H. Lee. 2003. Enhancement of chitooligosaccharides Doenjang (Soy Sauce) using Bacillus subtilis Koji and Rhizopus oryzae Koji. Kor. J. Food Sci. Technol. 35, 291-296
  7. Forman, D., D. G. Newell, F. Fullerton, J. W. Yarnell, A. R. Stacey, N. Wald and F. Sitas. 1991. Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation. Bri. Med. J. 302, 1302-1305 https://doi.org/10.1136/bmj.302.6788.1302
  8. Garrity, G. M., J. A. Bell and T. Lilburn. 1986. Family II. Helicobcteraceae fam. nov. pp. 1168-1198. In Sneath, P. H. A., N. S. Mair, M. E. Sharpe and J. G. Holt (eds.), Bergey's Manual of Systematic Bacteriology, Vol. 2, Williams & Wilkins. Baltimore
  9. Goodwin, C. S., J. A. Armstrong, T. Chilvers, M. Peters, M. D. Collins, L. Sly, W. McConell and W. E. S. Harper. 1989. Transfer of Campylobacter pylori and Campylobacter mustelae to Helicobacter gen. nov. as Helicobacter pylori com. nov. and Helicobacter mustelae com. nov., respectively. Int. J. Syst. Bacteriol. 39, 397-405 https://doi.org/10.1099/00207713-39-4-397
  10. Graham, D. Y., G. M. Lew, P. D., Klein, D. G. Evans, D. J. Jr. Evans, Z. A. Saeed and H. M. Malaty. 1992. Effect of treatment of Helicobacter pylori infection on the long-term recurrence of gastric or duodenal ulcer. Ann. Int. Med. 116, 705-708 https://doi.org/10.7326/0003-4819-116-9-705
  11. Kennedy, A. R. 1995. The evidence for soybean products as preventive agents. J. Nutr. 125, 733-739
  12. Kim, H. J., W. K. Chang, M. K. Kim, S. S. Lee and B. Y. Choi. 2002. Dietary factors and gastric cancer in Korea: a case-control study. Int. J. Cancer 97, 531-535 https://doi.org/10.1002/ijc.10111
  13. Kim, J. S., Y. J. Nam and J. W. Kwon. 1996. Induction of quinone reductase by soybean isoflavone, genistein. Food Sci. Biotechnol. 5, 70-75
  14. Kim, J. T., S. W. Nam, I. H. Roe, N. H. Myung and J. H. Shin. 2002. In vitro and in vivo investigation and verification of the substances with anti-Helicobacter pylori activity. Kor. J. Gastroenterol. 40, 166-172
  15. Kim, N. Y., S. H. Lim, K. H. Lee, M. S. Koo, J. M. Kim, J. H. Hwang, J. W. Kim, D. H. Lee, H. C. Jung and I. S. Song. 2003. Retreatment of Helicobacter pylori infection with triple therapy after initial treatment failure. Kor. J. Gastroenterol. 42, 195-203
  16. Kim, S. H., N. S. Choi, W. Y. Lee, J. W. Lee and D. H. Kim. 1998. Isolation of Bacillus strain secreting fibrinolytic enzymes from Doen-Jang. Kor. J. Microbiol. 34, 87-90
  17. Kim, Y. H. 2001. Ph. D. thesis: Genetic diversity and rapid diagnosis of Helicobacter pylori isolated from gastric ulcer tissue. pp. 1-14. Sunchon National University, Suncheon, Korea
  18. Lee, D. H. 2002. Current status and treatment of Helicobacter pylori infection in Korea. Kor. J. Gastroenterol. 39, 153-160
  19. Lee, S. A., D. Kang, K. N. Shim, J. W. Choe, W. S. Hong and H. Choi. 2003. Effect of diet and Helicobacter pylori infection to the risk of early gastric cancer. J. Epidemiol. 13, 162-168 https://doi.org/10.2188/jea.13.162
  20. Lin, H. J., W. C. Lo, C. L. Perng, A. F. Li, G. Y. Tseng, I. C. Sun and Y. H. Ou. 2004. Helicobacter pylori stool antigen test in patients with bleeding peptic ulcers. Helicobacter 9, 663-8 https://doi.org/10.1111/j.1083-4389.2004.00276.x
  21. Marshall, B. J., H. Royce, D. I. Annear, C. S. Goodwin, J. W. Pearman, J. R. Warren and J. A. Armstrong. 1984. Original isolation of Campylobacter pyloridis from human gastric mucosa. Microbios Lett. 25, 83-88
  22. Mokuolu, A. O., S. H. Sigal and C. S. Lieber. 1997. Gastric juice urease activity as a diagnostic test for Helicobacter pylori infection. Am. J. Gastroenterol. 92, 644-648
  23. Ndip, R. N., W. G. MacKay, M. J. Farthing and L. T. Weaver. 2003. Culturing Helicobacter pylori from clinical specimens: review of microbiologic methods. J. Pediatr. Gastroenterol. Nutr. 36, 616-622 https://doi.org/10.1097/00005176-200305000-00005
  24. Park, M. J., I. J. Choi, J. S. Kim, D. H. Lee, H. C. Jung, I. S. Song and C. Y. Kim. 2000. Efficacy of quadruple therapy as retreatment regimen in Helicobacter pylori-positive peptic ulcer disease. Kor. J. Gastroenterol. 36, 457-464
  25. Park, M. J., J. S. Kim, J. Y. Yim, H. C. Jung, I. S. Song, E. S. Yu, J. J. Lee, C. S. Huh and Y. J. Baek. 2001. The suppressive effect of a fermented milk containing Lactobacillus on Helicobacter pylori in human gastric mucosa. Kor. J. Gastroenterol 38, 233-240
  26. Piccolomini, R., G. D. Bonaventura and G. Catmo. 1997. Comparative evaluation of the E test, agar dilution, and broth microdilution for testing susceptibilities of Helicobacter pylori strains to 20 antimicrobial agents. J. Clin. Microbiol. 35, 1842-1846
  27. Picher, D. G., N. A. Saundrs and R. J. Owen. 1989. Rapid extraction of bacterial genomic DNA with guanidium thiocyanate. Lett. Appl. Microbiol. 8, 151-156 https://doi.org/10.1111/j.1472-765X.1989.tb00262.x
  28. Reed, K. D. and B. R. Berridge. 1988. Campylobacter-like organisms in the gastric mucosa of the rhesus monkeys. Lab. Ani. Sci. 38, 329-331
  29. Roe, I. H., S. W. Nam, N. H. Myung, J. T. Kim and J. H. Shin. 2002. In vitro and in vivo activities of garlic against Helicobacter pylori. Kor. J. Gastroenterol. 40, 159-165
  30. Roe, I. H., S. W. Nam, N. H. Myung, J. T. Kim and J. H. Shin. 2003. The Effect of mastic gum on Helicobacter pylori- infected gastritis. Kor. J. Gastroenterol. 41, 277-283
  31. Roe, I. H., S. W. Nam, M. R. Yang, N. H. Myung, J. T. Kim and J. H. Shin. 2002. The promising effect of egg yolk antibody (immunoglobulin yolk) on the treatment of Helicobacter pylori-associated gastric diseases. Kor. J. Gastroenterol. 39, 260-268
  32. Shin, Z. I., C. W. Ahn, H. S. Nam, H. J. Lee, H. J. Lee and T. H. Moon. 1995. Fractionation of angiotensin converting enzyme(ACE) inhibitory peptides from soybean paste. Kor. J. Food Sci. Technol. 27, 230-234