Effect of Extracts for Herbal Medicines on the Inhibition of Whole Blood Aggregation

한약재 추출물에 대한 전혈응집억제 효능 검색

  • Jeon, Won-Kyung (Department of Herbal Resources Research, Korea Institute of Oriental Medicine) ;
  • Yoo, Bo-Kyung (Herbal Quality Control Team, Korea Institute of Oriental Medicine) ;
  • Kim, Yeong-Eun (Herbal Quality Control Team, Korea Institute of Oriental Medicine) ;
  • Park, Sun-Ok (Herbal Quality Control Team, Korea Institute of Oriental Medicine) ;
  • Park, Sun-Min (Department of Food and Nutrition, Hoseo University) ;
  • Ko, Byoung-Seob (Herbal Quality Control Team, Korea Institute of Oriental Medicine)
  • 전원경 (한국한의학연구원 한약자원연구부) ;
  • 유보경 (한국한의학연구원 한약품질검사팀) ;
  • 김영은 (한국한의학연구원 한약품질검사팀) ;
  • 박선옥 (한국한의학연구원 한약품질검사팀) ;
  • 박선민 (호서대학교 식품영양학과) ;
  • 고병섭 (한국한의학연구원 한약품질검사팀)
  • Published : 2007.12.31

Abstract

For a correlation to study the five tastes and efficacies in oriental medicine concepts, we used herbal medicines with bitter taste character in traditionally effective and experimental methods. In this study, we tested the in vitro effect of 20 typical kinds of herbal medicines with bitter taste on platelet aggregation induced by collagen in human whole blood using the impedance method of aggregometry. Among them, 3 kinds of hot water extracts and 2 kinds of 70% ethanol extracts showed the significant inhibiting effect on whole blood aggregation $(^{***}p<0.001)$. In particular, Coptidis Rhizoma (Coptis chinensis) extracts were selected as the most effective candidate with a strong grade of bitter taste through the sensory test of trained panels. The results from this experiment provide pharmacological evidence for the traditional use of bitter tasting herbs with traditional medicine theory, suggesting that strong bitter taste herbs could be help problems of blood circulation more than mild bitter tasting herbs.

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