DOI QR코드

DOI QR Code

Anti-inflammatory Activities of Undaria pinnatifida and Laminaria japonica (Phaeophyta)

  • Published : 2007.09.30

Abstract

The anti-inflammatory activities of dichloromethane, ethanol, and boiling water extracts of the brown seaweeds Undaria pinnatifida (Harvey) Suringar and Laminaria japonica Areschoug were examined. Ethanol extracts (0.4 mg/ear) of U. pinnatifida inhibited inflammatory symptoms in mouse ear edema by 95.3%, and dichloromethane extract inhibited erythema by 65.5%. Dichloromethane and ethanol extracts (4 g/kg bw) of L. japonica demonstrated potent antipyretic activity. Activities of the seaweed extracts were similar to those of the commonly used drugs indomethacin and acetyl salicylic acid. No acute toxicity was observed after p.o. administration of each extract (5 g/kg bw). These results were in agreement with the claims of the health care industry and indigenous medicine that the above seaweeds can be used as an effective remedy for inflammation-related symptoms.

References

  1. Akio, M., N. Tomoki, W. Tatsuo, O. Takuya and M. Naotoshi. 1988. Pattern differences in experimental fevers induced by endotoxin endogenous pyrogen and prostaglandins. Am. J. Physiol., 254, R633-R640
  2. Chapman, C.R., K.I. Casey, R. Dubner, K.M. Foley, R.H. Gracely and A.E. Reading. 1985. Pain measurement: an overview. Pain, 22, 1-31
  3. Curtis, C.L., C.E. Hughes, C.R. Flannery, C.B. Little, J.L. Harwood and B. Caterson. 2000. n-3 Fatty acidsspecifically modulate catabolic factors involved in articular cartilage degradation. J. Biol, Chem., 275, 721-724 https://doi.org/10.1074/jbc.275.2.721
  4. Dascombe, M.J. 1985. The pharmacology of fever. Prog. Neurobiol., 25, 327-373 https://doi.org/10.1016/0301-0082(85)90019-X
  5. Donguibogam Committee. 1999. Translated Donguibogam. Bubinmunwha Press, Seoul, 1-2198
  6. Gray, W.D., AC. Osterberg, J.T. Scute. 1970. Measurement of the analgesic efficacy and potency of pentazocine by the D'Amour and Smith method. J. Pharmacol. Exp. Ther., 172, 154-162
  7. Griswold, D.E., L.D. Martin, A.M. Badger, J. Breton and M. Chabot-Fletcher. 1998. Evaluation of the cutaneous anti-inflammatory activity of azaspiranes. Inflamm. Res., 47, 56-61
  8. Heo, S.J., S.H. Cha, K.W. Lee, S.K. Cho and Y.J. Jeon. 2005. Aritioxidant activities of Chlorophyta and Phaeophyta from Jeju Island. Algae, 20, 251-260 https://doi.org/10.4490/ALGAE.2005.20.3.251
  9. Howard, M. 1993. Fever: causes and consequences. Neurosci. Biobehav. Rev., 17, 237-269 https://doi.org/10.1016/S0149-7634(05)80009-0
  10. Ikeda, K. 2002. New seasoning. Chem. Senses, 27, 847-849 https://doi.org/10.1093/chemse/27.9.847
  11. James, M.J., R.A. Gibson and L.G. Cleland. 2000. Dietary polyunsaturated fatty acids and inflammatory mediator production. Am. J. Clin. Nutr., 71, 343S-348S
  12. Kang, J.W. 1968. Illustrated Encyclopedia of Fauna & Flora of Korea: Marine Algae, Korea. Samhwa Press, Seoul, 1-465
  13. Lee, M.C., N. Konishi and H. Fujii. 2003. Blood flow analysis of skin tissue under the sacrum using laser speckle flowgraphy. Optic. Rev., 10, 562-566 https://doi.org/10.1007/s10043-003-0562-1
  14. Matsuzaki, S. and K. Iwamura. 1980. Application of seaweeds to human nutrition and medicine. In: Proceedings of the International Symposium for Food from the Sea. Noell, H., ed. Bremerhaven, Germany, 162-185
  15. MOMAF. 2007. Statistic Database for Fisheries Production. Retrieved from http://fs.fips.go.kr/main.jsp on July 14
  16. Muller-Decker, K., K. Scholz, E. Marks and G. Fustenberger. 1995. Differential expression of prostaglandin H synthase isozymes during multistage carcinogenesis in mouse epidermis. Mol. Carcinogen., 12, 31-41
  17. Nishizuka, Y. 1989. Studies and prospectives of the protein kinase C family for cellular regulation. Cancer, 63, 1892-1903 https://doi.org/10.1002/1097-0142(19890515)63:10<1892::AID-CNCR2820631005>3.0.CO;2-Z
  18. Scholz, J. and C.J. Wolf. 2002. Can we conquer pain? Nature Neurosci., 5, 1062-1067 https://doi.org/10.1038/nn942
  19. Smit, A.J. 2004. Medicinal and pharmaceutical uses of seaweed natural products: a review. J. Appl. Phycol., 16, 245-262 https://doi.org/10.1023/B:JAPH.0000047783.36600.ef
  20. Souza, A.L, F.A Moreira, K.R. Almeida, C.M. Bertollo, K.A. Costa and M.M. Coelho. 2002. In vivo evidence for a role of protein kinase C in peripheral nociceptive processing. Br. J. Pharmacol., 88, 544-548
  21. Suh, K. T. 1997. Classification of herbs in decoction part of Donguibogam. Ph.D. Thesis, Kyungsung University, Busan, Korea. 1-138
  22. Teotino, U.M., L.P. Friz, A. Gandini and D.D. Bella. 1963. Thio derivatives of 2,3 -dihydro-4H-1,3 -benzoazin -4-one synthesis and pharmacological properties. J. Med. Chem., 6, 248-250 https://doi.org/10.1021/jm00339a007
  23. Tseng, C.K. and C.P. Chang. 1984. Chinese seaweeds in herbal medicine. Hydrobiologia 116/117, 152-154 https://doi.org/10.1007/BF00027655
  24. Tsuchiya, M., A. Sakakibara and M. Yamamoto. 2005. A tachykinin NKI receptor antagonist attenuates the 4beta-phorbol-12-myristate-13-acetate- induced ociceptive behaviour in the rat. Eur. J. Pharmacol., 507, 29-34 https://doi.org/10.1016/j.ejphar.2004.11.028
  25. Wei, H. and K. Frenkel. 1992. Suppression of tumor promoter-induced oxidative events and DNA damage in vivo by sarcophytol A: a possible mechanism of antipromotion. Cancer Res., 52, 2298-2303
  26. WHO. 1992. Research Guidelines for Evaluating the Safety and Efficacy of Herbal Medicine. Regional Office for Western Pacific, Manila, Philippines, 1-38

Cited by

  1. Characteristics and in vitro Anti-diabetic Properties of the Korean Rice Wine, Makgeolli Fermented with Laminaria japonica vol.19, pp.2, 2014, https://doi.org/10.3746/pnf.2014.19.2.098
  2. Comparison of Saccharina japonica–Undaria pinnatifida Mixture and Minoxidil on Hair Growth Promoting Effect in Mice vol.43, pp.6, 2016, https://doi.org/10.5999/aps.2016.43.6.498