Antinociceptive and sedative effects of the bark of Cerbera odollam Gaertn.



Ahmed, Firoj;Hossain, M Hemayet;Rahman, Ahmed Ayedur;Shahid, Israt Zahan

  • 발행 : 2006.12.31


The crude methanolic extract of the bark of Cerbera odollam Gaertn. was evaluated for its possible antinociceptive and neuropharmacological activities in animal models. At the dose of 250 and 500 mg/kg body weight, the extract showed a significant antinociceptive effect in acetic acid induced writhing in mice comparable to that produced by aspirin, used as standard drug (P<0.001). The extract significantly reduced the time of onset of sleep (P<0.01) and potentiated the pentobarbital induced sleeping time in mice at the dose of 400 mg/kg of body weight significantly (P<0.001). It also decreased the open field score in open field test significantly at the dose of 400 mg/kg of body weight (P < 0.05). The obtained results tend to suggest the probable antinociceptive and neuropharmacological activities of the crude extract.


Cerbera odollam;Antinociceptive activity;CNS depressant activity


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