The Review on the Study related to Anti-inflammatory Mechanism of Bee Venom Therapy

봉독요법(蜂毒療法)의 항염증(抗炎症) 기전(機轉) 연구(硏究)에 관(關)한 고찰(考察)

  • Choi, Jung-Sik (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Gradate school of Daejeon University) ;
  • Park, Jang-Woo (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Gradate school of Daejeon University) ;
  • Oh, Min-Seok (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Gradate school of Daejeon University)
  • 최정식 (대전대학교 한의과대학 재활의학과학교실) ;
  • 박장우 (대전대학교 한의과대학 재활의학과학교실) ;
  • 오민석 (대전대학교 한의과대학 재활의학과학교실)
  • Accepted : 2006.04.22
  • Published : 2006.06.30

Abstract

The obtained results are summarized as follows 1. New findings are reporting year by year as for the study related to Anti-inflammatory mechanism of Bee Venom therapy. 2. The Anti-inflammatory effect of Bee Venom therapy is achieved through counterirritation, stimulations to adrenal cortex, immuno-regulation, antioxidation, removal of free radicals, modulation of AGP gene induction. 3. The chief components of Bee Venom related to Anti-inflammatory effect are Melittin, MCD peptide, Apamin, Adolapin etc. 4. Melittin binds to secretory phospholipase A2 and inhibits its enzymatic activity. 5. Melittin blocks neutophil O2-production. 6. MCD peptide(Peptide 401) stimulates the mast cell secrets histamine, Anti-inflammatory effect caused by this is 'conterirritation'. 7. Melittin & Apamin have an anti-inflammatory effect by inducing cortisone secretion. 8. MCD peptide & Apamin increase immunologic fuction by stimulating hypophysis & adrenal cortex and have an anti-inflammatory effect by inhibiting synthesis of prostaglandin from arachidonic acid. 9. Adolapin have an anti-inflammatory effect by inhibiting COX. 10. Bee Venom have an anti-inflammatory effect by suppressing AGP($\alpha$-acid glycoprotein). 11. Bee Venom have an anti-inflammatory effect by inhibiting NO, iNOS, PLA2, COX-2, TNF-$\alpha$, IL-1, NF-${\kappa}B$, MAP kinase.